Anti-Phospho-CYLD (Ser418) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-CYLD (Ser418). Anti-Phospho-CYLD (Ser418) Polyclonal Antibody 2 can be used in WB.

IgG

Mouse (predicted:Human,Rat,Dog,Pig,Cow,Horse)

WB: 1:500-2000

Polyclonal

KLH conjugated Synthesised phosphopeptide: human CYLD around the phosphorylation site of Ser418

Human

CYLD

Ubiquitin carboxyl-terminal hydrolase CYLD

Protease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Has endodeubiquitinase activity. Plays an important role in the regulation of pathways leading to NF-kappa-B activation. Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation. Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules. Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis. Required for normal cell cycle progress and normal cytokinesis. Inhibits nuclear translocation of NF-kappa-B. Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation. Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells. Negatively regulates TNFRSF11A signaling and osteoclastogenesis.