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Icosabutate

Name: Icosabutate
Brand: TargetMol
SKU: T15549
Price: 89 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T15549Cas No. 1253909-57-7

Alias PRC-4016, NST-4016

Icosabutate (NST-4016) is an orally active derivative of eicosapentaenoic acid that inhibits hepatic inflammation and fibrosis in NASH, improves cardiovascular risk profiles in statin-treated patients with residual hypertriglyceridemia, lowers triglycerides, and may be useful in studies of liver fibrosis and atherosclerosis.

Icosabutate

🥰Excellent

Purity: 98.58%

Catalog No. T15549Alias PRC-4016, NST-4016Cas No. 1253909-57-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$89	-	In Stock
5 mg	$197	-	In Stock
10 mg	$297	-	In Stock
25 mg	$619	-	In Stock
50 mg	$993	-	In Stock
100 mg	$1,630	-	In Stock
200 mg	$2,190	-	In Stock
1 mL x 10 mM (in DMSO)	$217	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:98.58%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Icosabutate (NST-4016) is an orally active derivative of eicosapentaenoic acid that inhibits hepatic inflammation and fibrosis in NASH, improves cardiovascular risk profiles in statin-treated patients with residual hypertriglyceridemia, lowers triglycerides, and may be useful in studies of liver fibrosis and atherosclerosis.
In vivo	In 6-8-week-old male ob/ob mice, Icosabutate (administered at 135 mg/kg/day through diet for 5 weeks) improved glucose metabolism and insulin resistance[1].
Synonyms	PRC-4016, NST-4016

Chemical Properties

Molecular Weight	374.56
Formula	C₂₄H₃₈O₃
Cas No.	1253909-57-7
Smiles	CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCCOC(CC)C(O)=O
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (213.58 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (8.81 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6698 mL	13.3490 mL	26.6980 mL	133.4900 mL
5 mM	0.5340 mL	2.6698 mL	5.3396 mL	26.6980 mL
10 mM	0.2670 mL	1.3349 mL	2.6698 mL	13.3490 mL
20 mM	0.1335 mL	0.6674 mL	1.3349 mL	6.6745 mL
50 mM	0.0534 mL	0.2670 mL	0.5340 mL	2.6698 mL
100 mM	0.0267 mL	0.1335 mL	0.2670 mL	1.3349 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc