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Icosabutate

Name: Icosabutate
Brand: TargetMol
SKU: T15549
Price: 81 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15549Cas No. 1253909-57-7

Alias PRC-4016, NST-4016

Icosabutate (NST-4016) is an orally active derivative of eicosapentaenoic acid that inhibits hepatic inflammation and fibrosis in NASH, improves cardiovascular risk profiles in statin-treated patients with residual hypertriglyceridemia, lowers triglycerides, and may be useful in studies of liver fibrosis and atherosclerosis.

Icosabutate

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Purity: 98.58%

Catalog No. T15549Alias PRC-4016, NST-4016Cas No. 1253909-57-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$81	-	In Stock
2 mg	$118	-	In Stock
5 mg	$197	-	In Stock
10 mg	$297	-	In Stock
25 mg	$619	-	In Stock
50 mg	$993	-	In Stock
100 mg	$1,630	-	In Stock
200 mg	$2,190	-	In Stock
1 mL x 10 mM (in DMSO)	$217	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:98.58%

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Icosabutate (NST-4016) is an orally active derivative of eicosapentaenoic acid that inhibits hepatic inflammation and fibrosis in NASH, improves cardiovascular risk profiles in statin-treated patients with residual hypertriglyceridemia, lowers triglycerides, and may be useful in studies of liver fibrosis and atherosclerosis.
In vivo	In 6-8-week-old male ob/ob mice, Icosabutate (administered at 135 mg/kg/day through diet for 5 weeks) improved glucose metabolism and insulin resistance[1].
Synonyms	PRC-4016, NST-4016

Chemical Properties

Molecular Weight	374.56
Formula	C₂₄H₃₈O₃
Cas No.	1253909-57-7
Smiles	CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCCOC(CC)C(O)=O
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (213.58 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (8.81 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6698 mL	13.3490 mL	26.6980 mL	133.4900 mL
5 mM	0.5340 mL	2.6698 mL	5.3396 mL	26.6980 mL
10 mM	0.2670 mL	1.3349 mL	2.6698 mL	13.3490 mL
20 mM	0.1335 mL	0.6674 mL	1.3349 mL	6.6745 mL
50 mM	0.0534 mL	0.2670 mL	0.5340 mL	2.6698 mL
100 mM	0.0267 mL	0.1335 mL	0.2670 mL	1.3349 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc