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Anti-CXCR4 Antibody (3O921)
😃Good
Catalog No. TMAH-00323
Alias WHIMS, WHIM, NPYY3R, NPYRL, NPYR, NPY3R, LESTR, LCR1, LAP-3, LAP3, HSY3RR, HM89, FB22, D2S201E, chemokine (C-X-C motif) receptor 4, CD184
Anti-CXCR4 Antibody (3O921) is an antibody targeting CXCR4. Anti-CXCR4 Antibody (3O921) can be used in ELISA.
Anti-CXCR4 Antibody (3O921)
Anti-CXCR4 Antibody (3O921)
😃Good
Catalog No. TMAH-00323Alias WHIMS, WHIM, NPYY3R, NPYRL, NPYR, NPY3R, LESTR, LCR1, LAP-3, LAP3, HSY3RR, HM89, FB22, D2S201E, chemokine (C-X-C motif) receptor 4, CD184
Anti-CXCR4 Antibody (3O921) is an antibody targeting CXCR4. Anti-CXCR4 Antibody (3O921) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $207 | 7-10 days | |
| 100 μL | $347 | 7-10 days |
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Chemical Properties
| Description | Anti-CXCR4 Antibody (3O921) is an antibody targeting CXCR4. Anti-CXCR4 Antibody (3O921) can be used in ELISA. |
| Alias | WHIMS, WHIM, NPYY3R, NPYRL, NPYR, NPY3R, LESTR, LCR1, LAP-3, LAP3, HSY3RR, HM89, FB22, D2S201E, chemokine (C-X-C motif) receptor 4, CD184 |
| Ig Type | Human IgG4(S228P) |
| Clone | 3O921 |
| Reactivity | Human |
| Verified Activity | The Binding Activity of Human CXCR4 with Anti-CXCR4 recombinant Antibody Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CXCR4 at 10 μg/mL can bind Anti-CXCR4 recombinant antibody, the EC50 is 101.7-253.6 ng/mL. |
| Application | ELISA |
| Antibody Type | Monoclonal |
| Subcellular Localization | Cell membrane; Multi-pass membrane protein. Cell junction. Early endosome. Late endosome. Lysosome. Note=In unstimulated cells, diffuse pattern on plasma membrane. On agonist stimulation, colocalizes with ITCH at the plasma membrane where it becomes ubiquitinated. In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation cluster (SMAC). |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| Research Background | Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade. Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. (Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) for human immunodeficiency virus-1/HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human CXCR4 Protein |
| Antigen Species | Human |
| Gene ID | 7852 |
| Uniprot ID | |
| Biology Area | Immunology |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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