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Anti-L-selectin Antibody (1A739)

😃Good
Catalog No. TMAY-02086
Alias selectin L

Anti-L-selectin Antibody (1A739) is a Rabbit antibody targeting L-selectin. Anti-L-selectin Antibody (1A739) can be used in ELISA(Cap).

Anti-L-selectin Antibody (1A739)

Anti-L-selectin Antibody (1A739)

😃Good
Catalog No. TMAY-02086Alias selectin L
Anti-L-selectin Antibody (1A739) is a Rabbit antibody targeting L-selectin. Anti-L-selectin Antibody (1A739) can be used in ELISA(Cap).
Pack SizePriceAvailabilityQuantity
20 μL$92 7-10 days
100 μL$268 7-10 days
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Product Introduction

Bioactivity
Description
Antibody Type: Rabbit Monoclonal

Application: ELISA(Cap)

Reactivity: Human
Aliasselectin L
Ig Type
Rabbit IgG
Clone
1A739
Reactivity
Human
Application
ELISA(Cap)
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionThis antibody was obtained from a rabbit immunized with purified, recombinant Human CD62L / L-Selectin (rh CD62L / L-Selectin; TMPY-02024; P14151-1; Met1-Asn332).
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundL-selectin (SELL), also known as CD62L, is a key adhesion molecule that regulates both the migration of leukocytes at sites of inflammation and the recirculation of lymphocytes between blood and lymphoid tissues. It belongs to the selectin family of proteins, and consisting of a large, highly glycosylated, extracellular domain, a single spanning transmembrane domain and a small cytoplasmic tail. L-selectin is the only selectin expressed on leukocytes and mediates a number of leukocyte-endothelial interactions. L-selectin acts as a "homing receptor" for leukocytes to enter secondary lymphoid tissues via high endothelial venules. Ligands present on endothelial cells will bind to leukocyte expressing L-selectin, slowing leukocyte trafficking through the blood, and facilitating entry into a secondary lymphoid organ at that point. L-selectin-mediated lymphocyte recirculation is required for maintaining the appropriate tissue distribution of lymphocyte subpopulations including naïve and effector subsets such as regulatory T cells. In addition, L-selectin-mediated entry into peripheral lymph nodes is required for optimal induction of lymphocyte homeostatic proliferation during lymphopenia. Importantly, L-selectin has been shown to have both adhesive and signaling functions during leukocyte migration. L-selectin has also been shown to mediate leukocyte recruitment during chronic inflammatory and autoimmune diseases and thus is a potential therapeutic target for drug development.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Protein: Human CD62L / L-Selectin Protein (TMPY-02024)
Antigen Species
Human
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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