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Anti-Notch1 Antibody (8D225)
😃Good
Catalog No. TMAB-09570
Anti-Notch1 Antibody (8D225) is a Rabbit antibody targeting Notch1. Anti-Notch1 Antibody (8D225) can be used in WB,IHC-P,IHC-Fr,IF,ICC/IF,FCM.
Anti-Notch1 Antibody (8D225)
Anti-Notch1 Antibody (8D225)
😃Good
Catalog No. TMAB-09570
Anti-Notch1 Antibody (8D225) is a Rabbit antibody targeting Notch1. Anti-Notch1 Antibody (8D225) can be used in WB,IHC-P,IHC-Fr,IF,ICC/IF,FCM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μL | $151 | 7-10 days | 7-10 days | |
| 50 μL | $264 | 7-10 days | 7-10 days | |
| 100 μL | $472 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Notch1 Antibody (8D225) is a Rabbit antibody targeting Notch1. Anti-Notch1 Antibody (8D225) can be used in WB,IHC-P,IHC-Fr,IF,ICC/IF,FCM. |
| Ig Type | IgG |
| Clone | 8D225 |
| Reactivity | Human,Mouse,Rat |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:200-800; IHC-Fr: 1:200-800; IF: 1:200-800; ICC/IF: 1:50-200; FCM: 1:50-100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cell membrane and Nucleus. Following proteolytical processing NICD is translocated to the nucleus. |
| Tissue Specificity | In fetal tissues most abundant in spleen, brain stem and lung. Also present in most adult tissues where it is found mainly in lymphoid tissues. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development. [provided by RefSeq, Jul 2008]. |
| Immunogen | A synthesized peptide: human Notch 1 |
| Antigen Species | Human |
| Gene Name | NOTCH1 |
| Gene ID | |
| Protein Name | Neurogenic locus notch homolog protein 1 |
| Uniprot ID | |
| Function | Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. May be important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, may function as a receptor for neuronal DNER and may be involved in the differentiation of Bergmann glia. |
| Molecular Weight | Theoretical: 271 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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