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GsMTx4
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Catalog No. TP1670 Copy Product Info
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GsMTx4 is a peptide inhibitor derived from spider venom that modulates mechanosensitive cation channels (MSCs), including stretch-activated channels (SACs) and certain TRP and Piezo-related channels. By inhibiting mechanosensitive channel activity, it has been shown in experimental models to reduce lysophosphatidylcholine-induced astrocyte toxicity and microglial reactivity, and is widely used as a pharmacological tool to study the physiological and pathological roles of mechanosensitive ion channels.
GsMTx4
Cas No. 1209500-46-8
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 500 µg | $222 | - | In Stock | |
| 1 mg | $413 | - | In Stock | |
| 5 mg | $1,160 | - | In Stock | |
| 10 mg | $1,560 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | GsMTx4 is a peptide inhibitor derived from spider venom that modulates mechanosensitive cation channels (MSCs), including stretch-activated channels (SACs) and certain TRP and Piezo-related channels. By inhibiting mechanosensitive channel activity, it has been shown in experimental models to reduce lysophosphatidylcholine-induced astrocyte toxicity and microglial reactivity, and is widely used as a pharmacological tool to study the physiological and pathological roles of mechanosensitive ion channels. |
| Molecular Weight | 4095.84 |
| Formula | C185H273N49O45S6 |
| Cas No. | 1209500-46-8 |
| Relative Density. | no data available |
| Sequence | Gly-Cys-Leu-Glu-Phe-Trp-Trp-Lys-Cys-Asn-Pro-Asn-Asp-Asp-Lys-Cys-Cys-Arg-Pro-Lys-Leu-Lys-Cys-Ser-Lys-Leu-Phe-Lys-Leu-Cys-Asn-Phe-Ser-Phe-NH₂ (Disulfide bridge:Cys2-Cys17;Cys9-Cys23;Cys16-Cys30) |
| Sequence Short | GCLEFWWKCNPNDDKCCRPKLKCSKLFKLCNFSF |
| Storage | Keep away from moisture,Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||
| Solubility Information | DMSO: 40.00 mg/mL (9.77 mM) | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: GsMTx4 formula | GsMTx4 molecular weight
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