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Ampicillin

Name: Ampicillin
Brand: TargetMol
SKU: T0814L
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0814LCas No. 69-53-4

Alias D-(-)-α-Aminobenzylpenicillin, Ampicillin acid, Aminobenzylpenicillin, Amcill

Ampicillin (Aminobenzylpenicillin) is a semi-synthetic penicillin belonging to the β-lactam group of antibiotics. Ampicillin has bactericidal activity against a wide range of Gram-positive and Gram-negative bacteria.

Ampicillin

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Purity: 99.59%

Catalog No. T0814LAlias D-(-)-α-Aminobenzylpenicillin, Ampicillin acid, Aminobenzylpenicillin, AmcillCas No. 69-53-4

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$42	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.59%

Color:White

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Product Introduction

Bioactivity

Description	Ampicillin (Aminobenzylpenicillin) is a semi-synthetic penicillin belonging to the β-lactam group of antibiotics. Ampicillin has bactericidal activity against a wide range of Gram-positive and Gram-negative bacteria.
Targets&IC50	transporter:9.9 mM (Ki), carnitine/carnitine antiport:7.6 mM, enzyme transpeptidase:1.8 µg/mL, HEK293 cells:> 100 μM (CC50)
In vitro	METHODS: E. coli was treated with Ampicillin (0.1-10 μG/mL) for 6 h. Growth was measured using a Fisher Electrophotometer. RESULTS: No differences in E. coli growth were observed at concentrations of 0, 0.1, and 1.0 μG. 2.5, 5, and 10 μG concentrations of Ampicillin inhibited E. coli growth. [1] METHODS: Pharyngeal cancer cells Detroit-562 were treated with Ampicillin (10-100 μM) for 72 h. Cell viability was measured by MTT. RESULTS: The Ampicillin-treated groups at concentrations of 10, 25 and 50 μM showed higher cell viability than the control cells, with values of 112%, 107% and 106%, respectively. At concentrations of 75 and 100 μM, there was a slight but not significant decrease in cell viability with values of approximately 95% and 94%, respectively. [2]
In vivo	METHODS: To test the neuroprotective mechanism in a mouse model of transient total forebrain ischemia, Ampicillin (200 mg/kg) was injected intraperitoneally into C57BL/6 mice once a day for five days, and forebrain ischemia was induced 24 h after the last injection. RESULTS: Pretreatment with Ampicillin significantly attenuated neuronal damage in the CA1 subregion of the hippocampus, and Ampicillin may provide neuroprotection against cerebral ischemia/reperfusion injury by inducing GLT-1 protein and inhibiting MMP activity in the hippocampus of mice. [3] METHODS: To study the in vivo activity, Ampicillin (10-100 mg/kg) was administered by gavage to C57BL/6 mice once daily for two days. RESULTS: Exposure of mice to Ampicillin induced anxiety and colitis, and increased Aspergillus flora in the gut microbiota. [4]
Synonyms	D-(-)-α-Aminobenzylpenicillin, Ampicillin acid, Aminobenzylpenicillin, Amcill

Chemical Properties

Molecular Weight	349.4
Formula	C₁₆H₁₉N₃O₄S
Cas No.	69-53-4
Smiles	[H][C@@]1(NC(=O)[C@H](N)c2ccccc2)C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@]12[H]
Relative Density.	1.2794 g/cm3 (Estimated)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 240 mg/mL (686.89 mM), Sonication is recommended.

0.1 M NaOH: 25 mg/mL (71.55 mM), Sonication is recommended.

Solution Preparation Table

0.1 M NaOH/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8620 mL	14.3102 mL	28.6205 mL	143.1025 mL
5 mM	0.5724 mL	2.8620 mL	5.7241 mL	28.6205 mL
10 mM	0.2862 mL	1.4310 mL	2.8620 mL	14.3102 mL
20 mM	0.1431 mL	0.7155 mL	1.4310 mL	7.1551 mL
50 mM	0.0572 mL	0.2862 mL	0.5724 mL	2.8620 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0286 mL	0.1431 mL	0.2862 mL	1.4310 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc