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Pyrogallol

Name: Pyrogallol
Brand: TargetMol
SKU: T3749
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3749Cas No. 87-66-1

Alias Piral, 1,2,3-trihydroxybenzene

Pyrogallol (Piral) is a white crystalline powder and a powerful reducing agent prepared by heating gallic acid.

Pyrogallol

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Purity: 99.91%

Catalog No. T3749Alias Piral, 1,2,3-trihydroxybenzeneCas No. 87-66-1

Pyrogallol (Piral) is a white crystalline powder and a powerful reducing agent prepared by heating gallic acid.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.91%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Pyrogallol AI Summary

Pyrogallol exhibits a wide range of bioactivities across various biological assays. It demonstrates in vitro antimalarial activity against Plasmodium falciparum with an IC50 value of 5660.0 nM and antibacterial activity against Staphylococcus epidermidis and Staphylococcus aureus with EC50 values of 990.0 nM and 490.0 nM, respectively. It acts as an antagonist at the LuxP receptor in Vibrio harveyi MM32, inhibiting autoinducer-2-mediated quorum sensing with an IC50 value of 2000.0 nM. Additionally, it shows quorum sensing inhibition-regulated bioluminescence in Vibrio harveyi with the same IC50. The compound exhibits antioxidant potential with several different measures, including an EC50 of 4200.0 nM in DPPH scavenging assays and an activity level of 0.12 /uM/s. It inhibits COX2 by 57.0% at 100 uM concentration and has an IC50 value of 144000.0 nM for the same enzyme. Additionally, it displays peroxidant property with a ratio of 1.38 and significant inhibition of COX2. Pyrogallol also shows substantial inhibition of rat intestinal sucrase with an IC50 greater than 500000.0 nM and inhibition rate of 42.0% at 500uM concentration. It has a partition coefficient of LogP 1.19 and demonstrates inhibitory activity against various enzymes, including Aldehyde Dehydrogenase 1 (ALDH1A1), Hydroxyacyl-Coenzyme A Dehydrogenase Type II (HADH2), and several others involved in metabolic and signaling pathways. It exhibits antifungal activity with minimum inhibitory concentrations (MICs) ranging from 12.5 ug/mL to >250.0 ug/mL against several fungal pathogens including Epidermophyton floccosum and Cryptococcus neoformans. For selectin inhibition, it demonstrates capacity to hinder cell attachment with varying degrees of inhibition for E-selectin, P-selectin, and L-selectin. It also acts as an enzyme inhibitor for carbonic anhydrase (CA) enzymes with inhibition constants (Ki) ranging from 520.0 nM to 7410.0 nM for different CA isoforms. Further, the compound has shown bioactivity as an inhibitor for enzymes like MMPs involved in extracellular matrix degradation and shows antiviral activity against SARS-CoV-2 with an IC50 greater than 20000.0 nM, indicating some, though not high, antiviral potential. Lastly, it manifests a significant inhibitory effect on various other enzymes and receptors, contributing to its capacity for impacting multiple physiological functions, including liver, kidney, and blood parameters. Overall, Pyrogallol showcases a comprehensive spectrum of bioactivities with varied potencies across different assays..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Pyrogallol (Piral) is a white crystalline powder and a powerful reducing agent prepared by heating gallic acid.
Synonyms	Piral, 1,2,3-trihydroxybenzene

Chemical Properties

Molecular Weight	126.11
Formula	C₆H₆O₃
Cas No.	87-66-1
Smiles	OC1=CC=CC(O)=C1O
Relative Density.	1.112 g/cm3 at 25℃ (lit.)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60.00 mg/mL (475.78 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.00 mg/mL (15.86 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	7.9296 mL	39.6479 mL	79.2959 mL	396.4793 mL
5 mM	1.5859 mL	7.9296 mL	15.8592 mL	79.2959 mL
10 mM	0.7930 mL	3.9648 mL	7.9296 mL	39.6479 mL
20 mM	0.3965 mL	1.9824 mL	3.9648 mL	19.8240 mL
50 mM	0.1586 mL	0.7930 mL	1.5859 mL	7.9296 mL
100 mM	0.0793 mL	0.3965 mL	0.7930 mL	3.9648 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc