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(R)-(-)-α-Methylhistamine dihydrobromide

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Catalog No. T12630Cas No. 868698-49-1

(R)-(-)-α-Methylhistamine dihydrobromide is a potent and selective H3 histamine receptor agonist with a dissociation constant (Kd) of 50.3 nM.

(R)-(-)-α-Methylhistamine dihydrobromide
Other Forms of (R)-(-)-α-Methylhistamine dihydrobromide:
(R)-(-)-α-Methylhistamine dihydrochlorideT2469875614-89-0
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(R)-(-)-α-Methylhistamine dihydrobromide

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Catalog No. T12630Cas No. 868698-49-1
(R)-(-)-α-Methylhistamine dihydrobromide is a potent and selective H3 histamine receptor agonist with a dissociation constant (Kd) of 50.3 nM.
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50 mg$2,72035 days
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Product Introduction

Bioactivity
Description
(R)-(-)-α-Methylhistamine dihydrobromide is a potent and selective H3 histamine receptor agonist with a dissociation constant (Kd) of 50.3 nM.
Targets&IC50
H3 receptor:50.3 nM (kd)
In vitro
(R)-(-)-α-Methylhistamine dihydrobromide is an H3-agonist with over 10 times the potency of histamine (HA). It exhibits weak affinities for H1 and H2 receptors, with pKi values of 4.8 and <3.5, respectively. The compound shows more than 1,000 times selectivity for H3-receptors compared to HA and over 200-fold selectivity over H4 receptors[1].
In vivo
(R)-alpha-Methylhistamine dihydrochloride (6.3 mg/kg; i.p.) significantly decreases the steady-state t-MH level in the mouse brain, whereas these compounds produced no significant changes in the HA level[2].Pretreatment with (R)-(-)-α-Methylhistamine dihydrobromide reverses propofol‐induced memory retention[4].
Chemical Properties
Molecular Weight287
FormulaC6H13Br2N3
Cas No.868698-49-1
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Keywords

α-Methylhistamine Dihydrobromideα-MethylhistamineHistamineReceptorHistamine ReceptorH3 Receptora-Methylhistamine Dihydrobromidea-Methylhistaminealpha-Methylhistamine Dihydrobromidealpha-Methylhistamine(R)()αMethylhistamine dihydrobromide(R) ( ) α Methylhistamine dihydrobromide
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