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Anti-SIRP beta 1 Antibody (4S571)
🥰Excellent
Catalog No. TMAY-03477
Anti-SIRP beta 1 Antibody (4S571) is a Rabbit antibody targeting SIRP beta 1. Anti-SIRP beta 1 Antibody (4S571) can be used in ELISA.
Anti-SIRP beta 1 Antibody (4S571)
Anti-SIRP beta 1 Antibody (4S571)
🥰Excellent
Catalog No. TMAY-03477
Anti-SIRP beta 1 Antibody (4S571) is a Rabbit antibody targeting SIRP beta 1. Anti-SIRP beta 1 Antibody (4S571) can be used in ELISA.
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Product Introduction
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Antigen Details
Chemical Properties
| Description | Anti-SIRP beta 1 Antibody (4S571) is a Rabbit antibody targeting SIRP beta 1. Anti-SIRP beta 1 Antibody (4S571) can be used in ELISA. |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 4S571 |
| Reactivity | Mouse |
| Application | ELISA |
| Recommended Dose | ELISA: 1:5000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse SIRPB1A (rM SIRPB1A; TMPY-02388; BAD26610.1; Met1-Lys363). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | SIRPB1A (Signal-regulatory protein beta 1A), also known as SIRP beta 1, belongs to signal-regulatory-protein (SIRP) family, and immunoglobulin superfamily. Signal-regulatory proteins (SIRPs) are cell-surface glycoproteins expressed on myeloid and neural cells that have been shown to recruit SH2 domain-containing protein phosphatase 1 (SHP-1) and SHP-2 and to regulate receptor tyrosine kinase-coupled signaling. SIRP are classified as SIRP alpha molecules, containing 11- to 113-amino acid long, or SIRP beta molecules, with a 5-amino acid long intracytoplasmic domain. SIRP beta 1 is a new DAP12-associated receptor involved in the activation of myeloid cells, which contains a short cytoplasmic domain that lacks sequence motifs capable of recruiting SHP-1 and SHP-2. SIRP beta 1 acts as an activating isoform of SIRP alpha molecules, confirming the co-existence of inhibitory ITIM-bearing molecules, recruiting SHP-1 and SHP-2 protein tyrosine phosphatases, and activating counterparts, whose engagement couples to protein tyrosine kinases via ITAM-bearing molecules.s |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Mouse SIRPB1A protein (TMPY-02388) |
| Antigen Species | Mouse |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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