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Prinaberel

Name: Prinaberel
Brand: TargetMol
SKU: TQ0149
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TQ0149Cas No. 524684-52-4

Alias WAY-202041, WAY202041, ERB041, ERB 041

Prinaberel (ERB 041) is a selective and potent estrogen receptor β (ERβ) agonist with anticancer activity that restores or increases ERβ expression and reduces cancer cell proliferation in mouse squamous cell carcinoma and human carcinoma cells. Prinaberel exhibits anti-inflammatory activity, inhibits the NFκB pro-inflammatory signaling pathway, and induces apoptosis of ovarian cancer cells. study endometriosis.

Prinaberel

😃Good

Purity: 97.10%

Catalog No. TQ0149Alias WAY-202041, WAY202041, ERB041, ERB 041Cas No. 524684-52-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$33	-	In Stock
5 mg	$84	-	In Stock
1 mL x 10 mM (in DMSO)	$100	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:97.10%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Prinaberel (ERB 041) is a selective and potent estrogen receptor β (ERβ) agonist with anticancer activity that restores or increases ERβ expression and reduces cancer cell proliferation in mouse squamous cell carcinoma and human carcinoma cells. Prinaberel exhibits anti-inflammatory activity, inhibits the NFκB pro-inflammatory signaling pathway, and induces apoptosis of ovarian cancer cells. study endometriosis.
Targets&IC50	ERβ (mouse):3.7 nM (IC50), ERα (rat):620 nM (IC50), ERα (human):1200 nM (IC50), ERβ (human):5.4 nM (IC50), ERα (mouse):750 nM (IC50), ERβ (rat):3.1 nM (IC50)
In vitro	Treatment of human squamous cell carcinoma (SCC) cells with Prinaberel (0-60 µM for 24 h) promoted cell differentiation, blocked the cell cycle, and reduced cell colony formation. In A431 cells, Prinaberel significantly decreased the expression of inflammation-regulating proteins such as p-NFκBp65, iNOS, and COX-2. Prinaberel inhibited the phosphorylation levels of PI3K and AKT, as well as enhanced the expression of E-cadherin, and reduced the migration ability of A431 cells. [2] Prinaberel (0.01-10 µM) inhibited cell proliferation in a dose- and time-dependent manner.Prinaberel (10 µM, 48 h) induced apoptosis in ovarian cancer cells (SKOV-3 cells). [3]
In vivo	In the SKH-1 nude mouse model, Prinaberel (2 mg/mouse, topical application, 30 minutes prior to UVB irradiation, weekly for 30 weeks) inhibited the development of squamous cell carcinoma.Prinaberel inhibited cell proliferation and angiogenesis, while promoting apoptosis, in UVB-induced skin tumors.Prinaberel also inhibited UVB Prinaberel also inhibited the pro-inflammatory signaling pathway in UVB-induced skin tumors and reduced tumor invasiveness by modulating the PI3K-AKT pathway and the WNT signaling pathway. [2]
Synonyms	WAY-202041, WAY202041, ERB041, ERB 041

Chemical Properties

Molecular Weight	271.24
Formula	C₁₅H₁₀FNO₃
Cas No.	524684-52-4
Smiles	FC=1C=C(C=CC1O)C2=NC3=CC(O)=CC(C=C)=C3O2
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (110.6 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (18.43 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6868 mL	18.4339 mL	36.8677 mL	184.3386 mL
5 mM	0.7374 mL	3.6868 mL	7.3735 mL	36.8677 mL
10 mM	0.3687 mL	1.8434 mL	3.6868 mL	18.4339 mL
20 mM	0.1843 mL	0.9217 mL	1.8434 mL	9.2169 mL
50 mM	0.0737 mL	0.3687 mL	0.7374 mL	3.6868 mL
100 mM	0.0369 mL	0.1843 mL	0.3687 mL	1.8434 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc