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Anti-IGF2R Domain 1-3 Antibody (3T816)
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Catalog No. TMAC-02441
Alias MPRI, MPR 300, M6PR, M6P/IGF2R, IGF-II receptor, CI-MPR, CD222
Anti-IGF2R Domain 1-3 Antibody (3T816) is a Rabbit antibody targeting IGF2R Domain 1-3. Anti-IGF2R Domain 1-3 Antibody (3T816) can be used in WB,ICC/IF,IHC,IP,FCM.
Anti-IGF2R Domain 1-3 Antibody (3T816)
Anti-IGF2R Domain 1-3 Antibody (3T816)
😃Good
Catalog No. TMAC-02441Alias MPRI, MPR 300, M6PR, M6P/IGF2R, IGF-II receptor, CI-MPR, CD222
Anti-IGF2R Domain 1-3 Antibody (3T816) is a Rabbit antibody targeting IGF2R Domain 1-3. Anti-IGF2R Domain 1-3 Antibody (3T816) can be used in WB,ICC/IF,IHC,IP,FCM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $297 | 7-10 days | |
| 100 μL | $498 | 7-10 days |
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| Description | Anti-IGF2R Domain 1-3 Antibody (3T816) is a Rabbit antibody targeting IGF2R Domain 1-3. Anti-IGF2R Domain 1-3 Antibody (3T816) can be used in WB,ICC/IF,IHC,IP,FCM. |
| Synonyms | MPRI, MPR 300, M6PR, M6P/IGF2R, IGF-II receptor, CI-MPR, CD222 |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat |
| Verified Activity | 1. Western blot analysis of M6PR on different cell lysates using anti-M6PR antibody at 1/1,000 dilution. Positive control: Lane 1: HepG2, Lane 2: SW480. 2. Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-M6PR antibody. Counter stained with hematoxylin. 3. ICC staining M6PR in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 4. ICC staining M6PR in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 5. ICC staining M6PR in HepG2 cells (green). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 6. Flow cytometric analysis of Hela cells with M6PR antibody at 1/50 dilution (blue) compared with an unlabelled control (cells without incubation with primary antibody; red). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody. |
| Application | |
| Recommended Dose | WB: 1:1000-10000; IHC: 1:50-200; ICC/IF: 1:50-200; FCM: 1:50-100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | The mannose 6-phosphate/insulin-like growth factor II receptor, IGF-IIR (also designated M6P/IGF2R), is a ubiquitously expressed integral glycoprotein. By binding glycoproteins through two of its extracytoplasmic domains, IGF-IIR mediates the activation of TGF??1 (a growth inhibitor), the degradation of IGF-II and the transport of lysosomal enzymes. Subsequently, IGF-IIR can form oligomeric complexes, which increase the affinity of IGF-IIR for lysosomal enzymes. Unlike IGF-IR, IGF-IIR does not potentiate the signaling of IGF-I or IGF-II, which have mitogenic, cell survival and insulin-like effects. Therefore, IGF-IIR is characterized as a tumor suppressor. Furthermore, the IGF-IIR gene is located on chromosome 6q26, which is commonly mutated or deleted in several human cancers. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein |
| Uniprot ID |
| Molecular Weight | Theoretical: 274 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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