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Anti-Phospho-BNIP3 (Ser95) Polyclonal Antibody
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Catalog No. TMAB-10408
Anti-Phospho-BNIP3 (Ser95) Polyclonal Antibody is a Rabbit antibody targeting Phospho-BNIP3 (Ser95). Anti-Phospho-BNIP3 (Ser95) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF,FCM.
Anti-Phospho-BNIP3 (Ser95) Polyclonal Antibody
Anti-Phospho-BNIP3 (Ser95) Polyclonal Antibody
😃Good
Catalog No. TMAB-10408
Anti-Phospho-BNIP3 (Ser95) Polyclonal Antibody is a Rabbit antibody targeting Phospho-BNIP3 (Ser95). Anti-Phospho-BNIP3 (Ser95) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF,FCM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $223 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Phospho-BNIP3 (Ser95) Polyclonal Antibody is a Rabbit antibody targeting Phospho-BNIP3 (Ser95). Anti-Phospho-BNIP3 (Ser95) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF,FCM. |
| Ig Type | IgG |
| Reactivity | Human (predicted:Dog,Cow,Horse,Sheep) |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; FCM: 1μg/Test |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Mitochondrion. Mitochondrion membrane. Coexpression with the EIB 19-kDa protein results in a shift in NIP3 localization pattern to the nuclear envelope. Colocalizes with ACAA2 in the mitochondria. |
| Construction | Hybridoma Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | The adenovirus E1B protein is a viral homolog of the Bcl-2 family of proteins that are involved in regulating cell death. A family of interacting proteins, which are designated Nip or Bnip and include BNIP-1, BNIP-2, BNIP-3 and Nix, associate with both the E1B protein and Bcl-2 proteins to mediate apoptotic signaling. BNIP-1 contains a hydrophobic transmembrane domain, which enables its localization to the nuclear envelope, endoplasmic recticulum and mitochondria. BNIP-2, (previously designated Nip2 and Nip21 in human and mouse respectively), shares homology with the non-catalytic domain of Cdc42 GTPase-activating protein (Cdc42GAP). Through binding to Cdc42GAP, BNIP-2 enhances the GTPase activity of Cdc42GAP, facilitating the hydrolysis of GTP bound to Cdc42 and thereby, mediating the signaling pathways involving receptor kinases, small GTPases and apoptotic proteins. Nix, which is also designated Nip3L or Bnip3L, is highly related to BNIP-3, and both proteins localize to the mitochondria where they associate with Bcl-2 proteins. BNIP-3 preferentially binds to Bcl-xL and induces apoptosis by suppressing the anti-apoptosis activity of Bcl-xL. |
| Immunogen | KLH conjugated synthesised phosphopeptide: human BNIP3 around the phosphorylation site of Ser95 |
| Antigen Species | Human |
| Gene Name | BNIP3 |
| Gene ID | |
| Protein Name | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 |
| Uniprot ID | |
| Function | Apoptosis-inducing protein that, which can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. |
| Molecular Weight | Theoretical: 22 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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