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NVP-CGM097 sulfate

Name: NVP-CGM097 sulfate
Brand: TargetMol
SKU: T12273
Rating: 4.5 (1 reviews)

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Catalog No. T12273Cas No. 1313367-56-4

Alias CGM097 sulfate

NVP-CGM097 sulfate is a potent and selective inhibitor of MDM2 [hMDM2], with an IC50 of 1.7±0.1 nM.

NVP-CGM097 sulfate

😃Good

Catalog No. T12273Alias CGM097 sulfateCas No. 1313367-56-4

NVP-CGM097 sulfate is a potent and selective inhibitor of MDM2 [hMDM2], with an IC50 of 1.7±0.1 nM.

Pack Size	Price	Availability
25 mg	$1,070	1-2 weeks
50 mg	$1,390	1-2 weeks
100 mg	$1,990	1-2 weeks

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Product Introduction

Bioactivity

Description	NVP-CGM097 sulfate is a potent and selective inhibitor of MDM2 [hMDM2], with an IC50 of 1.7±0.1 nM.
Targets&IC50	MDM2 (human):1.7±0.1 nM
In vitro	NVP-CGM097 is able to significantly redistribute wild-type p53 into the cell nucleus with an IC50 of 0.224 μM, demonstrating its ability to inhibit the p53:MDM2 interaction in living cells.?NVP-CGM097 significantly inhibits the proliferation of cells expressing wild-type p53, while sparing the p53 null cells with a 35-58-fold difference.?NVP-CGM097 inhibtis HCT116 (p53WT/WT) with IC50 of 454±136 nM[1].
Synonyms	CGM097 sulfate

Chemical Properties

Molecular Weight	757.34
Formula	C₃₈H₄₉ClN₄O₈S
Cas No.	1313367-56-4
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 140 mg/mL (184.86 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	1.3204 mL	6.6021 mL	13.2041 mL	66.0205 mL
5 mM	0.2641 mL	1.3204 mL	2.6408 mL	13.2041 mL
10 mM	0.1320 mL	0.6602 mL	1.3204 mL	6.6021 mL
20 mM	0.0660 mL	0.3301 mL	0.6602 mL	3.3010 mL
50 mM	0.0264 mL	0.1320 mL	0.2641 mL	1.3204 mL
100 mM	0.0132 mL	0.0660 mL	0.1320 mL	0.6602 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc