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NVP-CGM097 sulfate

Name: NVP-CGM097 sulfate
Brand: TargetMol
SKU: T12273
Rating: 4.5 (1 reviews)

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Catalog No. T12273Cas No. 1313367-56-4

Alias CGM097 sulfate

NVP-CGM097 sulfate is a potent and selective inhibitor of MDM2 [hMDM2], with an IC50 of 1.7±0.1 nM.

NVP-CGM097 sulfate

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Catalog No. T12273Alias CGM097 sulfateCas No. 1313367-56-4

NVP-CGM097 sulfate is a potent and selective inhibitor of MDM2 [hMDM2], with an IC50 of 1.7±0.1 nM.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,070	1-2 weeks	1-2 weeks
50 mg	$1,390	1-2 weeks	1-2 weeks
100 mg	$1,990	1-2 weeks	1-2 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	NVP-CGM097 sulfate is a potent and selective inhibitor of MDM2 [hMDM2], with an IC50 of 1.7±0.1 nM.
Targets&IC50	MDM2 (human):1.7±0.1 nM
In vitro	NVP-CGM097 is able to significantly redistribute wild-type p53 into the cell nucleus with an IC50 of 0.224 μM, demonstrating its ability to inhibit the p53:MDM2 interaction in living cells.?NVP-CGM097 significantly inhibits the proliferation of cells expressing wild-type p53, while sparing the p53 null cells with a 35-58-fold difference.?NVP-CGM097 inhibtis HCT116 (p53WT/WT) with IC50 of 454±136 nM[1].
Synonyms	CGM097 sulfate

Chemical Properties

Molecular Weight	757.34
Formula	C₃₈H₄₉ClN₄O₈S
Cas No.	1313367-56-4
Smiles	OS(O)(=O)=O.COc1cc2CC(=O)N([C@@H](c3ccc(Cl)cc3)c2cc1OC(C)C)c1ccc(cc1)N(C)C[C@H]1CC[C@@H](CC1)N1CCN(C)C(=O)C1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 140 mg/mL (184.86 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	1.3204 mL	6.6021 mL	13.2041 mL	66.0205 mL
5 mM	0.2641 mL	1.3204 mL	2.6408 mL	13.2041 mL
10 mM	0.1320 mL	0.6602 mL	1.3204 mL	6.6021 mL
20 mM	0.0660 mL	0.3301 mL	0.6602 mL	3.3010 mL
50 mM	0.0264 mL	0.1320 mL	0.2641 mL	1.3204 mL
100 mM	0.0132 mL	0.0660 mL	0.1320 mL	0.6602 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc