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Linoleoyl Ethanolamide

Name: Linoleoyl Ethanolamide
Brand: TargetMol
SKU: T8425
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8425Cas No. 68171-52-8

Linoleoyl Ethanolamide is an endocannabinoid agent. It acts by binding to TRPV1 increasing ERK phosphorylation and AP-1 dependent transcription in CB-receptor in an independent manner.

Linoleoyl Ethanolamide

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Purity: 99.97%

Catalog No. T8425Cas No. 68171-52-8

Linoleoyl Ethanolamide is an endocannabinoid agent. It acts by binding to TRPV1 increasing ERK phosphorylation and AP-1 dependent transcription in CB-receptor in an independent manner.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	-	In Stock
5 mg	$62	-	In Stock
10 mg	$92	-	In Stock
25 mg	$167	-	In Stock
50 mg	$251	-	In Stock
100 mg	$366	-	In Stock
200 mg	$549	-	In Stock
1 mL x 10 mM (in DMSO)	$77	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.97%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Linoleoyl Ethanolamide AI Summary

Linoleoyl Ethanolamide shows binding affinity towards cannabinoid receptors 1 and 2, with Ki values of 10000.0 nM for cannabinoid receptor 1 in the presence of PMSF, 40000.0 nM in its absence, and 25000.0 nM for cannabinoid receptor 2. It exhibits antiproliferative activity against human WI38 cells (63.0% at 10 uM after 48 hrs) and mouse RAW264.7 cells (100.0% at 10 uM after 48 hrs). The compound also inhibits rat recombinant FAAH with an IC50 of about 7580.0 to 7585.78 nM and demonstrates a hydrolysis rate of 0.98 nM min-1 mg-1 by rat brain microsomal anandamide amidohydrolase. Additionally, it acts as an agonist at the TRPV1 receptor (EC50 of 630.0 nM) and antagonist at recombinant rat TRPV2 (IC50 of 1400.0 nM for LPC-induced Ca2+ levels and 650.0 nM for CBD-induced Ca2+ levels). Furthermore, it exhibits broad inhibitory activity on various enzymes, including ALDH1A1 (8912.5 nM), HPGD (39810.7 nM), VDR (79432.8 nM), RGS4 at 106.2 nM, and APE1 (56234.1 nM). The compound shows antiallergic activity with an IC50 of 48000.0 nM in DNP-HSA-mediated degranulation assays, and exhibits other bioactivities, such as inhibition of transglutaminase in human keratinocytes and ARAT and LRAT in bovine RPE microsomes..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Linoleoyl Ethanolamide is an endocannabinoid agent. It acts by binding to TRPV1 increasing ERK phosphorylation and AP-1 dependent transcription in CB-receptor in an independent manner.

Chemical Properties

Molecular Weight	323.51
Formula	C₂₀H₃₇NO₂
Cas No.	68171-52-8
Smiles	CCCCCC=CCC=CCCCCCCCC(=O)NCCO
Relative Density.	0.926 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (77.28 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.18 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0911 mL	15.4555 mL	30.9109 mL	154.5547 mL
5 mM	0.6182 mL	3.0911 mL	6.1822 mL	30.9109 mL
10 mM	0.3091 mL	1.5455 mL	3.0911 mL	15.4555 mL
20 mM	0.1546 mL	0.7728 mL	1.5455 mL	7.7277 mL
50 mM	0.0618 mL	0.3091 mL	0.6182 mL	3.0911 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc