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DC-LC3in-D5

🥰Excellent
Catalog No. T61871Cas No. 2868312-73-4

DC-LC3in-D5 is a potent and selective covalent inhibitor of LC3A/B that disrupts autophagy by covalently binding to Lys49 on LC3B (IC₅₀ = 200 nM), resulting in impaired LC3B lipidation, accumulation of the autophagy substrate p62, and a significant reduction in the formation of autophagosome vesicles.

DC-LC3in-D5

DC-LC3in-D5

🥰Excellent
Purity: 99.79%
Catalog No. T61871Cas No. 2868312-73-4
DC-LC3in-D5 is a potent and selective covalent inhibitor of LC3A/B that disrupts autophagy by covalently binding to Lys49 on LC3B (IC₅₀ = 200 nM), resulting in impaired LC3B lipidation, accumulation of the autophagy substrate p62, and a significant reduction in the formation of autophagosome vesicles.
Pack SizePriceAvailabilityQuantity
1 mg$105In Stock
5 mg$259In Stock
10 mg$416In Stock
25 mg$852In Stock
50 mg$1,230In Stock
100 mg$1,930In Stock
200 mg$2,590In Stock
1 mL x 10 mM (in DMSO)$286In Stock
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Purity:99.79%
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Product Introduction

Bioactivity
Description
DC-LC3in-D5 is a potent and selective covalent inhibitor of LC3A/B that disrupts autophagy by covalently binding to Lys49 on LC3B (IC₅₀ = 200 nM), resulting in impaired LC3B lipidation, accumulation of the autophagy substrate p62, and a significant reduction in the formation of autophagosome vesicles.
In vitro
DC-LC3in-D5 selectively targets LC3A/B in HeLa cells. In vitro, treatment with DC-LC3in-D5 (3–30 μM, 16 h) disrupted LC3B lipidation, inhibited autophagosome formation, and led to significant accumulation of p62, indicating effective autophagy inhibition[1].
Chemical Properties
Molecular Weight397.3
FormulaC19H22Cl2N2O3
Cas No.2868312-73-4
SmilesO=C1C(=CNCCN2CCOCC2)C(=O)CC(C=3C=CC=C(Cl)C3Cl)C1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 30 mg/mL (75.51 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5170 mL12.5849 mL25.1699 mL125.8495 mL
5 mM0.5034 mL2.5170 mL5.0340 mL25.1699 mL
10 mM0.2517 mL1.2585 mL2.5170 mL12.5849 mL
20 mM0.1258 mL0.6292 mL1.2585 mL6.2925 mL
50 mM0.0503 mL0.2517 mL0.5034 mL2.5170 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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