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DC-LC3in-D5 is a potent and selective covalent inhibitor of LC3A/B that disrupts autophagy by covalently binding to Lys49 on LC3B (IC₅₀ = 200 nM), resulting in impaired LC3B lipidation, accumulation of the autophagy substrate p62, and a significant reduction in the formation of autophagosome vesicles.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $105 | In Stock | |
5 mg | $259 | In Stock | |
10 mg | $416 | In Stock | |
25 mg | $852 | In Stock | |
50 mg | $1,230 | In Stock | |
100 mg | $1,930 | In Stock | |
200 mg | $2,590 | In Stock | |
1 mL x 10 mM (in DMSO) | $286 | In Stock |
Description | DC-LC3in-D5 is a potent and selective covalent inhibitor of LC3A/B that disrupts autophagy by covalently binding to Lys49 on LC3B (IC₅₀ = 200 nM), resulting in impaired LC3B lipidation, accumulation of the autophagy substrate p62, and a significant reduction in the formation of autophagosome vesicles. |
In vitro | DC-LC3in-D5 selectively targets LC3A/B in HeLa cells. In vitro, treatment with DC-LC3in-D5 (3–30 μM, 16 h) disrupted LC3B lipidation, inhibited autophagosome formation, and led to significant accumulation of p62, indicating effective autophagy inhibition[1]. |
Molecular Weight | 397.3 |
Formula | C19H22Cl2N2O3 |
Cas No. | 2868312-73-4 |
Smiles | O=C1C(=CNCCN2CCOCC2)C(=O)CC(C=3C=CC=C(Cl)C3Cl)C1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 30 mg/mL (75.51 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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