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Anti-eRF3/GSPT1 Antibody (1V576)

Catalog No. TMAB-05663 Copy Product Info
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Anti-eRF3/GSPT1 Antibody (1V576) is a Rabbit antibody targeting eRF3/GSPT1. Anti-eRF3/GSPT1 Antibody (1V576) can be used in WB.

Anti-eRF3/GSPT1 Antibody (1V576)

Copy Product Info
🥰Excellent
Catalog No. TMAB-05663

Anti-eRF3/GSPT1 Antibody (1V576) is a Rabbit antibody targeting eRF3/GSPT1. Anti-eRF3/GSPT1 Antibody (1V576) can be used in WB.

Anti-eRF3/GSPT1 Antibody
(1V576)
Pack SizePriceUSA StockGlobal StockQuantity
25 μL$1487-10 days7-10 days
50 μL$2627-10 days7-10 days
100 μL$4737-10 days7-10 days
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
Anti-eRF3/GSPT1 Antibody (1V576) is a Rabbit antibody targeting eRF3/GSPT1. Anti-eRF3/GSPT1 Antibody (1V576) can be used in WB.
Ig Type
IgG
Clone
1V576
Reactivity
Human (predicted:Mouse,Rat)
Verified Activity
25 μg total protein per lane of various lysates (see on figure) probed with eGF3/GSPT1 monoclonal antibody, unconjugated (TMAB-05663) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r. T. for 60 min.
Application
Recommended Dose
WB: 1:500-2000
Antibody Type
Monoclonal
Host SpeciesRabbit
Subcellular LocalizationCytoplasmic.
ConstructionRecombinant Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundeRF3a is a 499 amino acid protein that belongs to the GTP-binding elongation factor family and is involved in the regulation of cell growth, specifically via control of translation termination. Human eRF3a shares 94% sequence identity with its mouse counterpart, suggesting a conserved function between species. The gene encoding eRF3a maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human eRF3/GSPT1
Gene Name
GSPT1
Gene ID
Protein Name
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
Function
Translation termination in eukaryotes is governed by two proteins, belonging to the class-1 (eRF1) and class-2 (eRF3) polypeptide release factors. eRF3/GSPT1 is involved in regulation of mammalian cell growth and belongs to the GTP-binding elongation factor family (ERF3 subfamily). eRF3 catalyzes hydrolysis of GTP to GDP and inorganic phosphate in the ribosome in the absence of mRNA, tRNA, aminoacyl-tRNA and peptidyl-tRNA.
Chemical Properties
Molecular WeightTheoretical: 56 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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