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Lecimibide

Name: Lecimibide
Brand: TargetMol
SKU: T25651
Price: 146 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T25651Cas No. 130804-35-2

Alias DuP-128, DuP128, DuP 128

Lecimibide (DuP 128) is a potent and selective inhibitor of acyl coenzyme A:cholesterol acyltransferase (ACAT), useful for studying high-lipid-related diseases.

Lecimibide

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Purity: 99.54%

Catalog No. T25651Alias DuP-128, DuP128, DuP 128Cas No. 130804-35-2

Lecimibide (DuP 128) is a potent and selective inhibitor of acyl coenzyme A:cholesterol acyltransferase (ACAT), useful for studying high-lipid-related diseases.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$146	In Stock	In Stock
5 mg	$350	In Stock	In Stock
10 mg	$530	In Stock	In Stock
25 mg	$859	In Stock	In Stock
50 mg	$1,180	-	In Stock
100 mg	$1,590	-	In Stock
500 mg	$3,190	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.54%

Appearance:Oil

Color:Yellow

Resource Download

COA HPLC FNMR HNMR

Product Introduction

Bioactivity

Description	Lecimibide (DuP 128) is a potent and selective inhibitor of acyl coenzyme A:cholesterol acyltransferase (ACAT), useful for studying high-lipid-related diseases.
In vitro	Lecimibide (DuP 128) (10 μM; 24 h) can inhibit 85% of the cellular esterification reaction in HepG2 cells.[1]
In vivo	Lecimibide (DuP 128) (2.2 mg/kg/day.; i.v) significantly reduced total plasma triglyceride and very low-density lipoprotein (VLDL) triglyceride concentrations in pigs fed high fat and cholesterol, respectively 36% and 31%. There were no significant effects on total cholesterol, VLDL cholesterol, LDL cholesterol, HDL cholesterol, or LDL apo B concentrations.[2]
Synonyms	DuP-128, DuP128, DuP 128

Chemical Properties

Molecular Weight	590.77
Formula	C₃₄H₄₀F₂N₄OS
Cas No.	130804-35-2
Smiles	S(CCCCCN(C(NC1=C(F)C=C(F)C=C1)=O)CCCCCCC)C=2NC(=C(N2)C3=CC=CC=C3)C4=CC=CC=C4
Relative Density.	1.21g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (93.1 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6927 mL	8.4635 mL	16.9271 mL	84.6353 mL
5 mM	0.3385 mL	1.6927 mL	3.3854 mL	16.9271 mL
10 mM	0.1693 mL	0.8464 mL	1.6927 mL	8.4635 mL
20 mM	0.0846 mL	0.4232 mL	0.8464 mL	4.2318 mL
50 mM	0.0339 mL	0.1693 mL	0.3385 mL	1.6927 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc