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Lecimibide

Name: Lecimibide
Brand: TargetMol
SKU: T25651
Price: 146 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T25651Cas No. 130804-35-2

Alias DuP-128, DuP128, DuP 128

Lecimibide (DuP 128) is a potent and selective inhibitor of acyl coenzyme A:cholesterol acyltransferase (ACAT), useful for studying high-lipid-related diseases.

Lecimibide

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Purity: 99.87%

Catalog No. T25651Alias DuP-128, DuP128, DuP 128Cas No. 130804-35-2

Lecimibide (DuP 128) is a potent and selective inhibitor of acyl coenzyme A:cholesterol acyltransferase (ACAT), useful for studying high-lipid-related diseases.

Pack Size	Price	Availability
1 mg	$146	In Stock
5 mg	$350	In Stock
10 mg	$530	In Stock
25 mg	$859	In Stock
50 mg	$1,180	In Stock
100 mg	$1,590	In Stock
500 mg	$3,190	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.87%

Resource Download

COA FNMR HNMR LCMS

Product Introduction

Bioactivity

Description	Lecimibide (DuP 128) is a potent and selective inhibitor of acyl coenzyme A:cholesterol acyltransferase (ACAT), useful for studying high-lipid-related diseases.
In vitro	Lecimibide (DuP 128) (10 μM; 24 h) can inhibit 85% of the cellular esterification reaction in HepG2 cells.[1]
In vivo	Lecimibide (DuP 128) (2.2 mg/kg/day.; i.v) significantly reduced total plasma triglyceride and very low-density lipoprotein (VLDL) triglyceride concentrations in pigs fed high fat and cholesterol, respectively 36% and 31%. There were no significant effects on total cholesterol, VLDL cholesterol, LDL cholesterol, HDL cholesterol, or LDL apo B concentrations.[2]
Synonyms	DuP-128, DuP128, DuP 128

Chemical Properties

Molecular Weight	590.77
Formula	C₃₄H₄₀F₂N₄OS
Cas No.	130804-35-2
Smiles	S(CCCCCN(C(NC1=C(F)C=C(F)C=C1)=O)CCCCCCC)C=2NC(=C(N2)C3=CC=CC=C3)C4=CC=CC=C4
Relative Density.	1.21g/cm3

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (93.1 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6927 mL	8.4635 mL	16.9271 mL	84.6353 mL
5 mM	0.3385 mL	1.6927 mL	3.3854 mL	16.9271 mL
10 mM	0.1693 mL	0.8464 mL	1.6927 mL	8.4635 mL
20 mM	0.0846 mL	0.4232 mL	0.8464 mL	4.2318 mL
50 mM	0.0339 mL	0.1693 mL	0.3385 mL	1.6927 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc