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Anti-SEMA4D Antibody (8V558)

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Catalog No. TMAB-12643

Anti-SEMA4D Antibody (8V558) is a Rabbit antibody targeting SEMA4D. Anti-SEMA4D Antibody (8V558) can be used in ICC/IF, IF, IHC-Fr, IHC-P, WB.

Anti-SEMA4D Antibody (8V558)

Anti-SEMA4D Antibody (8V558)

😃Good
Catalog No. TMAB-12643
Anti-SEMA4D Antibody (8V558) is a Rabbit antibody targeting SEMA4D. Anti-SEMA4D Antibody (8V558) can be used in ICC/IF, IF, IHC-Fr, IHC-P, WB.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 μL$1507-10 days7-10 days
50 μL$2617-10 days7-10 days
100 μL$4707-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-SEMA4D Antibody (8V558) is a Rabbit antibody targeting SEMA4D. Anti-SEMA4D Antibody (8V558) can be used in ICC/IF, IF, IHC-Fr, IHC-P, WB.
Ig Type
IgG
Clone
8V558
Reactivity
Human
Application
ICC/IF
IF
IHC-Fr
IHC-P
WB
Recommended Dose
ICC/IF=1:50-200; IF=1:100-500; IHC-Fr=1:100-500; IHC-P=1:100-500; WB=1:500-2000
Antibody Type
Monoclonal
Host SpeciesRabbit
Subcellular LocalizationMembrane.
Tissue SpecificityStrongly expressed in skeletal muscle, peripheral blood lymphocytes, spleen, and thymus and also expressed at lower levels in testes, brain, kidney, small intestine, prostate, heart, placenta, lung and pancreas, but not in colon and liver.
ConstructionRecombinant Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
Research BackgroundCell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling.Regulates GABAergic synapse development.
Antigen Details
Immunogen
A synthesized peptide: human Semaphorin 4D
Antigen Species
Human
Gene Name
SEMA4D
Gene ID
10507
Protein Name
Semaphorin-4D
Uniprot ID
Q92854
Function
Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Interaction with PLXNB1 mediates activation of RHOA.
Chemical Properties
Molecular WeightTheoretical: 96 kDa. Actual: 120, 140 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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