Contact UsQuotation
Shopping Cart
Remove All
  • TargetMol
    Your shopping cart is currently empty
Proceed to checkoutContinue shopping
TOPBioactivityChemical infoStorage&SolubilityCalculator

Protease-Activated Receptor-1, PAR-1 Agonist TFA

Copy Product Info
😃Good
Catalog No. T36288

Protease-Activated Receptor-1 (PAR-1) Agonist TFA is a selective peptide that acts as an agonist for the proteinase-activated receptor-1 (PAR-1). Corresponding to the tethered ligand of PAR-1, this compound mimics the actions of thrombin through the PAR-1 receptor[1][2].

Protease-Activated Receptor-1, PAR-1 Agonist TFA

Protease-Activated Receptor-1, PAR-1 Agonist TFA

Copy Product Info
😃Good
Catalog No. T36288
Protease-Activated Receptor-1 (PAR-1) Agonist TFA is a selective peptide that acts as an agonist for the proteinase-activated receptor-1 (PAR-1). Corresponding to the tethered ligand of PAR-1, this compound mimics the actions of thrombin through the PAR-1 receptor[1][2].
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 mgInquiryInquiryInquiry
100 mgInquiryInquiryInquiry
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Questions
TargetMol
View More

Resource Download

Product Introduction

Bioactivity
Description
Protease-Activated Receptor-1 (PAR-1) Agonist TFA is a selective peptide that acts as an agonist for the proteinase-activated receptor-1 (PAR-1). Corresponding to the tethered ligand of PAR-1, this compound mimics the actions of thrombin through the PAR-1 receptor[1][2].
In vitro
A Protease-Activated Receptor-1 (PAR-1) agonist triggers the activation of protein kinase C (PKC) isoforms alpha and epsilon in HT-29 colon carcinoma cells that endogenously express PAR1. This stimulation at the cellular level, induced by both the PAR-1 agonist and thrombin, leads to enhanced HT-29 cell migration and matrix adhesion through a PKCepsilon-dependent pathway. This conclusion is supported by the observation that the effects mediated by PAR1 are inhibited by bisindolylmaleimide I (a PKC inhibitor) and EAVSLKPT (a PKCepsilon translocation inhibitory peptide), but not by PKC inhibitor G? 6976[2].
Chemical Properties
Relative Density.no data available
SequenceThr-Phe-Leu-Leu-Arg-Asn
Sequence ShortTFLLRN
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 6.67 mg/mL, Sonication and heating to 60℃ are recommended.

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Protease-Activated Receptor-1, PAR-1 Agonist TFAProteaseActivated Receptor1, PAR1 Agonist TFAProtease Activated Receptor 1, PAR 1 Agonist TFA
Related Tags: buy Protease-Activated Receptor-1, PAR-1 Agonist TFA | purchase Protease-Activated Receptor-1, PAR-1 Agonist TFA | Protease-Activated Receptor-1, PAR-1 Agonist TFA cost | order Protease-Activated Receptor-1, PAR-1 Agonist TFA | Protease-Activated Receptor-1, PAR-1 Agonist TFA in vitro
TargetMol | Logo

Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.