MIP-1 alpha/CCL3 Protein, Mouse, Recombinant (His)

Name: MIP-1 alpha/CCL3 Protein, Mouse, Recombinant (His)
Brand: TargetMol
SKU: TMPJ-00831
Rating: 4.5 (1 reviews)

(Synonyms: Scya3, MIP1-a, MIP-1 α, MIP-1 alpha, Macrophage inflammatory protein 1-α, Macrophage inflammatory protein 1-alpha, LD78a, LD78 α, LD78 alpha, Heparin-binding chemotaxis protein, chemokine (C-C motif) ligand 3, C-C motif chemokine 3) Copy Product Info

Synonyms: Scya3, MIP1-a, MIP-1 α, MIP-1 alpha, Macrophage inflammatory protein 1-α, Macrophage inflammatory protein 1-alpha, LD78a, LD78 α, LD78 alpha, Heparin-binding chemotaxis protein, chemokine (C-C motif) ligand 3, C-C motif chemokine 3

Catalog No. TMPJ-00831 Copy Product Info

C-C Motif Chemokine 3 (MIP-1 alpha,CCL3 ) is a member of the beta or CC subfamily of chemokines and is closely related to CCL4/MIP-1 beta. CCL3 expression can be induced in a variety of hematopoietic cells, fibroblasts, smooth muscle cells, and epithelial cells. Mature mouse CCL3 shares 73%, 91%, and 82% amino acid sequence identity with human, rat, and cotton rat CCL3, respectively. CCL3 exerts its biological functions through interactions with CCR1, CCR3, and CCR5. It is cleared from the extracellular space by internalization via the decoy chemokine receptor D6. CCL3 promotes the chemoattraction, adhesion to activated vascular endothelium, and cellular activation of many hematopoietic cell types including activated T cells, NK cells, neutrophils, monocytes, immature dendritic cells, and eosinophils. CCL3 is also known as stem cell inhibitor (SCI) and can inhibit the proliferation of hematopoietic progenitor cells. CCL3 bioactivity contributes to tumor metastasis and the inflammatory components of viral infection, rheumatoid arthritis, and hepatitis, although it also can suppress the replication of HIV.

MIP-1 alpha/CCL3 Protein, Mouse, Recombinant (His)

Pack Size	Price	USA Stock	Global Stock
5 μg	$112	7-10 days	7-10 days
10 μg	$183	7-10 days	7-10 days
20 μg	$292	7-10 days	7-10 days
50 μg	$545	7-10 days	7-10 days
100 μg	$813	7-10 days	7-10 days
200 μg	$1,190	7-10 days	7-10 days
500 μg	$2,070	7-10 days	7-10 days
1 mg	$2,970	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:Greater than 95% as determined by reducing SDS-PAGE.

Appearance:Lyophilized powder

Color:White

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity


Description	C-C Motif Chemokine 3 (MIP-1 alpha,CCL3 ) is a member of the beta or CC subfamily of chemokines and is closely related to CCL4/MIP-1 beta. CCL3 expression can be induced in a variety of hematopoietic cells, fibroblasts, smooth muscle cells, and epithelial cells. Mature mouse CCL3 shares 73%, 91%, and 82% amino acid sequence identity with human, rat, and cotton rat CCL3, respectively. CCL3 exerts its biological functions through interactions with CCR1, CCR3, and CCR5. It is cleared from the extracellular space by internalization via the decoy chemokine receptor D6. CCL3 promotes the chemoattraction, adhesion to activated vascular endothelium, and cellular activation of many hematopoietic cell types including activated T cells, NK cells, neutrophils, monocytes, immature dendritic cells, and eosinophils. CCL3 is also known as stem cell inhibitor (SCI) and can inhibit the proliferation of hematopoietic progenitor cells. CCL3 bioactivity contributes to tumor metastasis and the inflammatory components of viral infection, rheumatoid arthritis, and hepatitis, although it also can suppress the replication of HIV.
Species	Mouse
Expression System	E. coli
Tag	N-6xHis
Accession Number	P10855
Amino Acid	Ala24-Ala92
Construction	Ala24-Ala92
Protein Purity	Greater than 95% as determined by reducing SDS-PAGE. Greater than 95% as determined by SEC-HPLC.
Endotoxin	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM Tris-HCl, 150 mM NaCl, 5%Trehalose, 1 mM EDTA, pH 8.0.
Reconstitution	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Stability & Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Synonyms	Scya3, MIP1-a, MIP-1 α, MIP-1 alpha, Macrophage inflammatory protein 1-α, Macrophage inflammatory protein 1-alpha, LD78a, LD78 α, LD78 alpha, Heparin-binding chemotaxis protein, chemokine (C-C motif) ligand 3, C-C motif chemokine 3
Research Background

Chemical Properties

Molecular Weight

15 KDa (reducing condition)

Storage & Solubility Information

Storage

Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Related Tags: MIP-1 alpha/CCL3 Protein, Mouse, Recombinant (His) chemical structure | MIP-1 alpha/CCL3 Protein, Mouse, Recombinant (His) molecular weight