Powder: -20°C for 3 years | In solvent: -80°C for 1 year
YM-244769 (3-Pyridinecarboxamide, N-[(3-aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]-) is an effective inhibitor of Na+/Ca2+ exchange 3 (NCX3) with an IC50 of 18 nM. YM-244769 has efficient protective effects on neurons and kidneys.
Pack Size | Availability | Price/USD | Quantity |
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2 mg | 5 days | $ 44.00 |
Description | YM-244769 (3-Pyridinecarboxamide, N-[(3-aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]-) is an effective inhibitor of Na+/Ca2+ exchange 3 (NCX3) with an IC50 of 18 nM. YM-244769 has efficient protective effects on neurons and kidneys. |
Targets&IC50 | NCX3:18 nM |
In vitro | YM-244769 (0.3 or 1 μM) efficiently suppresses the hypoxia/reoxygenation-induced cell damage in SH-SY5Y cells treated with NCX1 antisense (i.e., SH-SY5Y cells primarily expressing NCX3) more than in those treated with NCX3 antisense (i.e., SH-SY5Y cells primarily expressing NCX1). YM-244769 (0.003-1 μM) inhibits the initial rates of 45 Ca 2+ uptake into NCX1, NCX2, and NCX3 transfectants with IC 50 values of 68±2.9, 96±3.5, and 18±1.0 nM, respectively, indicating that YM-244769 is approximately four to five times more selective to NCX3 than other isoforms[1]. |
Synonyms | 3-Pyridinecarboxamide, N-[(3-aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]- |
Molecular Weight | 443.47 |
Formula | C26H22FN3O3 |
CAS No. | 838819-70-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 245 mg/mL (552.46 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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YM-244769 838819-70-8 Membrane transporter/Ion channel Metabolism Calcium Channel 3-Pyridinecarboxamide, N-[(3-aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]- nicotinamide Na+/Ca2+ exchange neuroprotective YM244769 NCX3 SH-SY5Y cells Inhibitor anti-ischemic inhibit LLC-PK1 cells Na+/Ca2+ Exchanger YM 244769 inhibitor