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Anti-S1P/Subtilisin isozyme 1 Polyclonal Antibody
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Catalog No. TMAB-12465
Anti-S1P/Subtilisin isozyme 1 Polyclonal Antibody is a Rabbit antibody targeting S1P/Subtilisin isozyme 1. Anti-S1P/Subtilisin isozyme 1 Polyclonal Antibody can be used in WB.
Anti-S1P/Subtilisin isozyme 1 Polyclonal Antibody
Anti-S1P/Subtilisin isozyme 1 Polyclonal Antibody
😃Good
Catalog No. TMAB-12465
Anti-S1P/Subtilisin isozyme 1 Polyclonal Antibody is a Rabbit antibody targeting S1P/Subtilisin isozyme 1. Anti-S1P/Subtilisin isozyme 1 Polyclonal Antibody can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-S1P/Subtilisin isozyme 1 Polyclonal Antibody is a Rabbit antibody targeting S1P/Subtilisin isozyme 1. Anti-S1P/Subtilisin isozyme 1 Polyclonal Antibody can be used in WB. |
| Ig Type | IgG |
| Reactivity | Mouse (predicted:Human,Rat,Chicken,Rabbit) |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Widely expressed. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the cis/medial-Golgi where a second autocatalytic event takes place and the catalytic activity is acquired. It encodes a type 1 membrane bound protease which is ubiquitously expressed and regulates cholesterol or lipid homeostasis via cleavage of substrates at non-basic residues. Mutations in this gene may be associated with lysosomal dysfunction. [provided by RefSeq, Feb 2014] |
| Immunogen | KLH conjugated synthetic peptide: human S1P/Subtilisin isozyme 1 |
| Antigen Species | Human |
| Gene Name | MBTPS1 |
| Gene ID | |
| Protein Name | Membrane-bound transcription factor site-1 protease |
| Uniprot ID | |
| Function | Serine protease that catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF, GNPTAB and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysosomes. |
| Molecular Weight | Theoretical: 96 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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