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Anti-CEACAM3 Antibody (7Z451)
😃Good
Catalog No. TMAY-02152
Alias W282, W264, MGC119875, CGM1, CEA, CD66D, carcinoembryonic antigen related cell adhesion molecule 3
Anti-CEACAM3 Antibody (7Z451) is a Mouse antibody targeting CEACAM3. Anti-CEACAM3 Antibody (7Z451) can be used in FCM.
Anti-CEACAM3 Antibody (7Z451)
Anti-CEACAM3 Antibody (7Z451)
😃Good
Catalog No. TMAY-02152Alias W282, W264, MGC119875, CGM1, CEA, CD66D, carcinoembryonic antigen related cell adhesion molecule 3
Anti-CEACAM3 Antibody (7Z451) is a Mouse antibody targeting CEACAM3. Anti-CEACAM3 Antibody (7Z451) can be used in FCM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $198 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-CEACAM3 Antibody (7Z451) is a Mouse antibody targeting CEACAM3. Anti-CEACAM3 Antibody (7Z451) can be used in FCM. |
| Alias | W282, W264, MGC119875, CGM1, CEA, CD66D, carcinoembryonic antigen related cell adhesion molecule 3 |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 7Z451 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of anti-human CEACAM3 (CD66d) on human whole blood granulocytes. The fluorescence histograms were derived from events with the forward and side light-scatter characteristics of viable granulocytes. Flow cytometry was performed using a BD FACS Calibur Flow Cytometer System. |
| Application | FCM |
| Recommended Dose | FCM: 1:25-1:100 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CEACAM3 / CD66d (rh CEACAM3 / CD66d; TMPY-01850; NP_001806.2; Met1-Gly155). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | CeACAM3 (CD66d), a member of carcinoembryonic antigen family, is a granulocyte-specific receptor involved in the opsonin-independent recognition of several bacterial pathogens. There are four members in this family: CD66a, CD66b, CD66c, and CD66d. Members of CEACAM family are widely expressed especially on human neutrophils, and, depending on the tissue, capable of regulating diverse functions including tumor promotion, tumor suppression, angiogenesis, and neutrophil activation. Abnormal overexpression and downregulation of some CEACAMs have been described in tumor cells. Monoclonal antibodies grouped in the CD66 cluster recognize CEACAM members. Ectopic CD66 expression is commonly detected in B-cell lineage acute lymphoblastic leukemia (ALL). CEACAM3 mediates phagocytosis depends on the integrity of an ITAM-like sequence within the cytoplasmic domain of CEACAM3. CEACAM3 is characterized by rapid stimulation of the GTPase Rac. |
| Conjucates | Unconjugated |
| Others Formats | PE |
| Antibody Types Available | 2 |
| Immunogen | Recombinant Human CEACAM3 / CD66d protein (TMPY-01850) |
| Antigen Species | Human |
| Biology Area | ITIM/ITAM Immunoreceptors and Related Molecules |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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