PD0166285 dihydrochloride

Name: PD0166285 dihydrochloride
Brand: TargetMol
SKU: T6931L
Rating: 4.5 (1 reviews)

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Catalog No. T6931LCas No. 212391-63-4

Alias PD-166285

PD-166285 is an effective and broadly active inhibitor of protein tyrosine kinase.

PD0166285 dihydrochloride

😃Good

Catalog No. T6931LAlias PD-166285Cas No. 212391-63-4

PD-166285 is an effective and broadly active inhibitor of protein tyrosine kinase.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$133	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	PD-166285 is an effective and broadly active inhibitor of protein tyrosine kinase.
Targets&IC50	Myt1:72 nM (IC50), Chk1:3.433 μM (IC50), Wee1:24 nM (IC50)
Synonyms	PD-166285

Chemical Properties

Molecular Weight	585.35
Formula	C₂₆H₂₉Cl₄N₅O₂
Cas No.	212391-63-4
Smiles	O=C1C(C2=C(C=CC=C2Cl)Cl)=CC3=C(N1C)N=C(NC4=CC=C(C=C4)OCCN(CC)CC)N=C3.Cl.Cl
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	DMSO: Soluble

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc