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SB-209670

Name: SB-209670
Brand: TargetMol
SKU: T34541
Price: 350 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T34541Cas No. 157659-79-5

Alias SB 209670

SB-209670 is a selective endothelin receptor antagonist that inhibits the activity of ET(B) receptors in rat vascular endothelium and vascular smooth muscle.

SB-209670

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Purity: 99.40%

Catalog No. T34541Alias SB 209670Cas No. 157659-79-5

SB-209670 is a selective endothelin receptor antagonist that inhibits the activity of ET(B) receptors in rat vascular endothelium and vascular smooth muscle.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$350	In Stock	In Stock
5 mg	$828	In Stock	In Stock
10 mg	$1,130	In Stock	In Stock
25 mg	$1,590	In Stock	In Stock
50 mg	$1,980	In Stock	In Stock
100 mg	$2,500	-	In Stock
500 mg	$4,900	-	In Stock
1 mL x 10 mM (in DMSO)	$838	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.40%

ee:100%

Appearance:Solid

Color:White to Orange

Resource Download

COA ORP HNMR LCMS CSFC

Product Introduction

Bioactivity

Description	SB-209670 is a selective endothelin receptor antagonist that inhibits the activity of ET(B) receptors in rat vascular endothelium and vascular smooth muscle.
In vivo	SB 209670 (3 mg kg-1, i.v. bolus + 100 micrograms kg-1, i.v. infusion commencing 15 min prior to LPS ; rats) significantly augmented the hypotension as well as the vascular hyporeactivity to NA caused by endotoxaemia.[5] SB 209670 (3 mg kg-1, i.v. bolus given 15 min prior to LPS ; LPS-rats) resulted in a reduction in 6 h-survival from 71% (control) to 30% and 13%, respectively.[5] SB 209670 (3 mg kg-1, i.v. bolus 15 min prior to LPS ; rats) significantly augmented the serum levels of creatinine, bilirubin, GPT and GOT caused by endotoxin.[5] SB 209670 (3 mg kg-1, i.v. bolus ; rats) significantly augmented the metabolic acidosis caused by LPS.[5]
Synonyms	SB 209670

Chemical Properties

Molecular Weight	520.53
Formula	C₂₉H₂₈O₉
Cas No.	157659-79-5
Smiles	C(O)(=O)[C@H]1[C@@H](C=2C([C@@H]1C=3C=C4C(=CC3)OCO4)=CC=C(OCCC)C2)C5=C(OCC(O)=O)C=C(OC)C=C5
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 27.5 mg/mL (52.83 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9211 mL	9.6056 mL	19.2112 mL	96.0559 mL
5 mM	0.3842 mL	1.9211 mL	3.8422 mL	19.2112 mL
10 mM	0.1921 mL	0.9606 mL	1.9211 mL	9.6056 mL
20 mM	0.0961 mL	0.4803 mL	0.9606 mL	4.8028 mL
50 mM	0.0384 mL	0.1921 mL	0.3842 mL	1.9211 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc