Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

Anti-BMI-1 Antibody (4I124)

😃Good
Catalog No. TMAC-00455

Anti-BMI-1 Antibody (4I124) is a Rabbit antibody targeting BMI-1. Anti-BMI-1 Antibody (4I124) can be used in WB,ICC/IF,IHC.

Anti-BMI-1 Antibody (4I124)

Anti-BMI-1 Antibody (4I124)

😃Good
Catalog No. TMAC-00455
Anti-BMI-1 Antibody (4I124) is a Rabbit antibody targeting BMI-1. Anti-BMI-1 Antibody (4I124) can be used in WB,ICC/IF,IHC.
Pack SizePriceAvailabilityQuantity
50 μL$2977-10 days
100 μL$4967-10 days
Add to Cart
Add to Quotation
Bulk & Custom
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Questions
View More

Product Introduction

Bioactivity
Description
Anti-BMI-1 Antibody (4I124) is a Rabbit antibody targeting BMI-1. Anti-BMI-1 Antibody (4I124) can be used in WB,ICC/IF,IHC.
Ig Type
IgG
Reactivity
Human,Rat
Application
Recommended Dose
WB: 1:1000-2000; IHC: 1:50-200; ICC/IF: 1:50-200
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionRecombinant Antibody
PurificationProA affinity purified
AppearanceLiquid
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Research BackgroundIn Drosophila, Polycomb (Pc-g) gene family encodes chromatin proteins that are required for the repression of homeotic loci in embryonic development. Mel-18 and Bmi-1, mammalian homologs of Drosophila Pc-g group proteins, are similarly expressed during development and implicated in the regulation of gene expression, axial skeleton development, control of proliferation and survival of haematopoietic cells. Mel-18 directly binds to DNA through a RING-finger motif and preferentially associates with juxtaposed enhancer elements on various genes, including Bcl-2, c-Myc and Hox. Mel-18 is an immediate early response gene within the c-Myc/Cdc25 signaling cascade that exhibits tumor suppressor activity and negatively regulates cell cycle progression by blocking S phase entry. Alternatively, Bmi-1 has been identified as a potent oncogene as it contributes to the transcriptional activation of genes implicated in early lymphoid development. Proviral activation of Bmi-1 expression corresponds to enhanced gene-specific activation of other proto-oncogenes, including c-Myc and Pim, subsequently resulting in the progression of lymphomagenesis.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Protein
Antigen Species
Recombinant Protein
Uniprot ID
Chemical Properties
Molecular WeightTheoretical: 42 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Related Tags: buy Anti-BMI-1 Antibody (4I124) | purchase Anti-BMI-1 Antibody (4I124) | Anti-BMI-1 Antibody (4I124) cost | order Anti-BMI-1 Antibody (4I124) | Anti-BMI-1 Antibody (4I124) molecular weight