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AG-024322

Name: AG-024322
Brand: TargetMol
SKU: T14136
Price: 699 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14136Cas No. 837364-57-5

Alias AG-024322, AG024322, AG 024322

AG-024322 is a potent ATP-competitive inhibitor targeting pan-CDK, effectively inhibiting cell cycle kinases CDK1, CDK2, and CDK4 with Ki values in the 1-3 nM range (1-3 nM).

AG-024322

🥰Excellent

Purity: 98.53%

Catalog No. T14136Alias AG-024322, AG024322, AG 024322Cas No. 837364-57-5

AG-024322 is a potent ATP-competitive inhibitor targeting pan-CDK, effectively inhibiting cell cycle kinases CDK1, CDK2, and CDK4 with Ki values in the 1-3 nM range (1-3 nM).

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$699	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.53%

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COA LCMS

Product Introduction

Bioactivity

Description	AG-024322 is a potent ATP-competitive inhibitor targeting pan-CDK, effectively inhibiting cell cycle kinases CDK1, CDK2, and CDK4 with Ki values in the 1-3 nM range (1-3 nM).
Targets&IC50	HCT116 cells:120 nM, CDK2:3 nM （ki）, CDK4:2.9 nM (Ki), CDK1:2.3 nM (Ki), CDK1:2.3 nM （ki）, CDK2:3 nM (Ki), CDK4:2.9 nM （ki）
In vitro	Biotin-PEG4-Picolyl azide can utilize the ubiquitin-proteasome system to achieve selective elimination of target proteins through E3 ubiquitin ligase-mediated specific degradation of target proteins [1].
In vivo	In male and female cynomolgus monkeys, AG-024322 (at doses of 2, 6, and 10 mg/kg; intravenous infusion; over 5 days) resulted in dose-dependent pancytopenic bone marrow hypocellularity and lymphoid depletion in lymph nodes, spleen, and/or thymus at doses greater than 6 mg/kg[1].
Synonyms	AG-024322, AG024322, AG 024322

Chemical Properties

Molecular Weight	418.44
Formula	C₂₃H₂₀F₂N₆
Cas No.	837364-57-5
Smiles	CCNCc1cncc(-c2ccc3[nH]nc(-c4nc5cc(F)cc(F)c5[nH]4)c3c2)c1C
Relative Density.	1.361 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (191.19 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.89 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3898 mL	11.9491 mL	23.8983 mL	119.4914 mL
5 mM	0.4780 mL	2.3898 mL	4.7797 mL	23.8983 mL
10 mM	0.2390 mL	1.1949 mL	2.3898 mL	11.9491 mL
20 mM	0.1195 mL	0.5975 mL	1.1949 mL	5.9746 mL
50 mM	0.0478 mL	0.2390 mL	0.4780 mL	2.3898 mL
100 mM	0.0239 mL	0.1195 mL	0.2390 mL	1.1949 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc