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Efloxate
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Catalog No. T0151Cas No. 119-41-5
Alias Angorlisin
Efloxate (Angorlisin), a vasodilator, is utilized in the treatment of chronic coronary insufficiency.
Efloxate
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Purity: 99.66%
Catalog No. T0151Alias AngorlisinCas No. 119-41-5
Efloxate (Angorlisin), a vasodilator, is utilized in the treatment of chronic coronary insufficiency.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $37 | In Stock | In Stock | |
| 50 mg | $52 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.66%
Appearance:Solid
Color:Yellow
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Product Introduction
Efloxate AI Summary
Efloxate exhibits inhibitory activity across a range of bioassays, targeting entities such as human Jumonji domain-containing 2E, Mycobacterium tuberculosis H37Rv, Influenza NS1 protein function, malarial parasite plastid TGF-b, firefly luciferase, ClpP activators, gsp agonists, GLP-1 receptor agonists, and gametocytocidal compounds, with potencies ranging from 48.1 nM to 35481.3 nM. It shows high clearance rates in human liver microsomes, with values exceeding 300.0 mL.min-1.g-1 at 1 μM concentration. The compound demonstrates antiviral activity against SARS-CoV-2, inhibiting virus-induced cytotoxicity in both Caco-2 and VERO-6 cells, though with relatively moderate potency, evidenced by inhibition percentages of -3.96% and 0.15% at 10 μM after 48-hour exposure, and an IC50 value greater than 20000.0 nM. Additionally, it inhibits SARS-CoV-2 3CL-Pro protease by 11.81% at a concentration of 20 μM. In assays involving human HDAC6, Efloxate shows mixed results with 46.4% inhibition using a commercial peptide substrate and reverse activity (-3.12% inhibition) with a custom peptide substrate..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Efloxate (Angorlisin), a vasodilator, is utilized in the treatment of chronic coronary insufficiency. |
| Synonyms | Angorlisin |
| Molecular Weight | 324.33 |
| Formula | C19H16O5 |
| Cas No. | 119-41-5 |
| Smiles | CCOC(=O)COc1ccc2c(c1)oc(cc2=O)-c1ccccc1 |
| Relative Density. | 1.265g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: Slightly soluble  |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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