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CRBN modulator-1

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Catalog No. T8824Cas No. 2407829-65-4
Alias WUN29654

CRBN modulator-1 (WUN29654) is a Thalidomide analog and CRBN modulator,has an IC50 of 3.5 μM and a Ki of 0.98 μM.

CRBN modulator-1

CRBN modulator-1

😃Good
Purity: 99.36%
Catalog No. T8824Alias WUN29654Cas No. 2407829-65-4
CRBN modulator-1 (WUN29654) is a Thalidomide analog and CRBN modulator,has an IC50 of 3.5 μM and a Ki of 0.98 μM.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$33In StockIn Stock
5 mg$73In StockIn Stock
10 mg$118In StockIn Stock
25 mg$223In StockIn Stock
50 mg$333In StockIn Stock
100 mg$469In StockIn Stock
500 mgPreferential-In Stock
1 mL x 10 mM (in DMSO)$79In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.36%
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
CRBN modulator-1 (WUN29654) is a Thalidomide analog and CRBN modulator,has an IC50 of 3.5 μM and a Ki of 0.98 μM.
SynonymsWUN29654
Chemical Properties
Molecular Weight324.29
FormulaC17H12N2O5
Cas No.2407829-65-4
SmilesOc1cc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c3cccc(c1)c23
Relative Density.1.587 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 3.25 mg/mL (10.02 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.0837 mL15.4183 mL30.8366 mL154.1830 mL
5 mM0.6167 mL3.0837 mL6.1673 mL30.8366 mL
10 mM0.3084 mL1.5418 mL3.0837 mL15.4183 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

WUN-29654WUN 29654Ligands for E3 LigaseLigandforE3LigaseLigand for E3 LigaseInhibitorinhibitE3 ligase-recruiting MoietyCRBN modulator-1CRBN modulator1CRBN modulator 1
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