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MMK 1 acetate

Catalog No. TP1891L1 CAS TP1891L1

Synonyms: MMK 1 acetate(271246-66-3 free base)

MMK 1 acetate is an agonist of formyl peptide receptor 2 (FPR2), which was previously known as formyl peptide receptor-like 1 (FPRL1) [1].

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MMK 1 acetate, CAS TP1891L1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 197.00
5 mg	In stock	$ 443.00
10 mg	In stock	$ 655.00
25 mg	In stock	$ 987.00
50 mg	In stock	$ 1,390.00
100 mg	In stock	$ 1,880.00
500 mg	In stock	$ 3,770.00

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Description	MMK 1 acetate is an agonist of formyl peptide receptor 2 (FPR2), which was previously known as formyl peptide receptor-like 1 (FPRL1) [1].
In vitro	MMK1 induced calcium flux in CHO cells expressing human FPR2 and Gα16 (EC50 = <2 nM) but not in CHO cells expressing Gα16 alone or in combination with FPR1 (EC50s = >10,000 nM for both). It induced chemotaxis of isolated human peripheral blood monocytes and neutrophils in a concentration-dependent manner [2]. MMK1 (10 µM) increases production of the proinflammatory cytokines IL-1β and IL-6 in isolated human monocytes [3].
In vivo	Intracerebroventricular administration of MMK1 (100 pmol/mouse) increases the percentage of time spent in the open arms of the elevated plus maze in mice, indicating anxiolytic-like activity [3].

Synonyms	MMK 1 acetate(271246-66-3 free base)
Molecular Weight	1671.01
Formula	C77H127N19O20S
CAS No.	TP1891L1

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. C Klein, et al.Identification of surrogate agonists for the human FPRL-1 receptor by autocrine selection in yeastNat. Biotechnol.16(13)1334-1337(1998). 2. J Y Hu, et al. Synthetic peptide MMK-1 is a highly specific chemotactic agonist for leukocyte FPRL1J. Leukoc. Biol.70(1)155-161(2001). 3. Hui Zhao, et al. Rubimetide, humanin, and MMK1 exert anxiolytic-like activities via the formyl peptide receptor 2 in mice followed by the successive activation of DP1, A2A, and GABAA receptors. Peptides. 2016 Sep;83:16-20.

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Keywords

MMK 1 acetate TP1891L1 Others MMK 1 acetate(271246-66-3 free base) MMK 1 Acetate MMK-1 Acetate MMK1 Acetate inhibitor inhibit

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