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EST64454 hydrochloride

Name: EST64454 hydrochloride
Brand: TargetMol
SKU: T8834
Rating: 4.5 (1 reviews)

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Catalog No. T8834Cas No. 1950569-11-5

Alias EST64454 HCL

EST64454 hydrochloride (EST64454) is a highly soluble σ1 receptor antagonist (Ki : 22 nM),has the potential for Pain Management.

EST64454 hydrochloride

😃Good

Catalog No. T8834Alias EST64454 HCLCas No. 1950569-11-5

EST64454 hydrochloride (EST64454) is a highly soluble σ1 receptor antagonist (Ki : 22 nM),has the potential for Pain Management.

Pack Size	Price	Availability
2 mg	$37	Backorder
5 mg	$59	Backorder
10 mg	$98	Backorder
25 mg	$208	Backorder
50 mg	$337	Backorder
100 mg	$535	Backorder
200 mg	$735	Backorder
1 mL x 10 mM (in DMSO)	$74	Backorder

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Product Introduction

Bioactivity

Description	EST64454 hydrochloride (EST64454) is a highly soluble σ1 receptor antagonist (Ki : 22 nM),has the potential for Pain Management.
Targets&IC50	σ1:22 nM(Ki)
Synonyms	EST64454 HCL

Chemical Properties

Molecular Weight	400.85
Formula	C₁₈H₂₃ClF₂N₄O₂
Cas No.	1950569-11-5
Smiles	Cl.CC(=O)N1CCN(CCOCc2ccn(n2)-c2ccc(F)c(F)c2)CC1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (49.89 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4947 mL	12.4735 mL	24.9470 mL	124.7349 mL
5 mM	0.4989 mL	2.4947 mL	4.9894 mL	24.9470 mL
10 mM	0.2495 mL	1.2473 mL	2.4947 mL	12.4735 mL
20 mM	0.1247 mL	0.6237 mL	1.2473 mL	6.2367 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc