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KL1333

Name: KL1333
Brand: TargetMol
SKU: T16342
Price: 95 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16342Cas No. 1800405-30-4

Alias NQO1 activator 1

KL1333 (NQO1 activator 1) enhances energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. Elevated NAD+ levels trigger the activation of SIRT1 and AMPK, and subsequently activates PGC-1α. NQO1 activator 1 is an orally available NAD+ modulator. It reacts with NAD(P)H: NQO1 as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation.

KL1333

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Purity: 99.89%

Catalog No. T16342Alias NQO1 activator 1Cas No. 1800405-30-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$95	In Stock	In Stock
5 mg	$192	In Stock	In Stock
10 mg	$289	In Stock	In Stock
25 mg	$523	In Stock	In Stock
50 mg	$787	In Stock	In Stock
100 mg	$1,070	-	In Stock
1 mL x 10 mM (in DMSO)	$253	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.89%

Appearance:Solid

Color:Red

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	KL1333 (NQO1 activator 1) enhances energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. Elevated NAD+ levels trigger the activation of SIRT1 and AMPK, and subsequently activates PGC-1α. NQO1 activator 1 is an orally available NAD+ modulator. It reacts with NAD(P)H: NQO1 as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation.
Synonyms	NQO1 activator 1

Chemical Properties

Molecular Weight	240.26
Formula	C₁₄H₁₂N₂O₂
Cas No.	1800405-30-4
Smiles	CC(C)c1nc-2c([nH]1)C(=O)C(=O)c1ccccc-21
Relative Density.	1.329 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 245 mg/mL (1019.73 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (20.81 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.1622 mL	20.8108 mL	41.6216 mL	208.1079 mL
5 mM	0.8324 mL	4.1622 mL	8.3243 mL	41.6216 mL
10 mM	0.4162 mL	2.0811 mL	4.1622 mL	20.8108 mL
20 mM	0.2081 mL	1.0405 mL	2.0811 mL	10.4054 mL
50 mM	0.0832 mL	0.4162 mL	0.8324 mL	4.1622 mL
100 mM	0.0416 mL	0.2081 mL	0.4162 mL	2.0811 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc