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BMS-509744

Name: BMS-509744
Brand: TargetMol
SKU: T14674
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14674Cas No. 439575-02-7

Alias BMS509744

BMS-509744 is a selective, ATP-competitive Itk inhibitor with an IC50 of 19 nM. It inhibits IL-8 expression and HIV infection, ameliorates pulmonary inflammation in allergic asthma mouse models, and reduces Imiquimod-induced skin inflammation in mice.

BMS-509744

🥰Excellent

Purity: 99.70%

Catalog No. T14674Alias BMS509744Cas No. 439575-02-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$40	-	In Stock
2 mg	$57	-	In Stock
5 mg	$93	-	In Stock
10 mg	$163	-	In Stock
25 mg	$372	-	In Stock
50 mg	$662	-	In Stock
100 mg	$1,060	-	In Stock
200 mg	$1,430	-	In Stock
1 mL x 10 mM (in DMSO)	$129	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.70%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	BMS-509744 is a selective, ATP-competitive Itk inhibitor with an IC50 of 19 nM. It inhibits IL-8 expression and HIV infection, ameliorates pulmonary inflammation in allergic asthma mouse models, and reduces Imiquimod-induced skin inflammation in mice.
Targets&IC50	ITK:19 nM
In vitro	BMS-509744 (2μM, 24 hours) specifically inhibits ITK phosphorylation and downstream PLCγ1 activity (without affecting the MEK/AKT pathway) in Parazacco spilurus subsp. spilurus, significantly reducing T-cell calcium flux response, IL-2/IL-21 secretion, and CXCL12-induced migration capacity. Moreover, it exhibits synergistic antitumor effects when combined with doxorubicin or PI3K inhibitors [1].
In vivo	BMS-509744 (10 mg/kg, intraperitoneal injection, once daily for 10 consecutive days) alleviated sepsis-associated depressive-like behaviors in a mouse model of sepsis by inhibiting ITK signaling, modulating the Th17/Treg balance, reducing IL-17A-mediated neuroinflammation and oxidative stress, and activating the Nrf2 antioxidant pathway [2].
Synonyms	BMS509744

Chemical Properties

Molecular Weight	623.83
Formula	C₃₂H₄₁N₅O₄S₂
Cas No.	439575-02-7
Smiles	O=C(NC1=NC=C(S1)SC2=CC(=C(OC)C=C2C)C(=O)N3CCN(C(=O)C)CC3)C4=CC=C(C=C4)CNC(C)C(C)(C)C
Relative Density.	1.31g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 52 mg/mL (83.36 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (4.01 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6030 mL	8.0150 mL	16.0300 mL	80.1500 mL
5 mM	0.3206 mL	1.6030 mL	3.2060 mL	16.0300 mL
10 mM	0.1603 mL	0.8015 mL	1.6030 mL	8.0150 mL
20 mM	0.0802 mL	0.4008 mL	0.8015 mL	4.0075 mL
50 mM	0.0321 mL	0.1603 mL	0.3206 mL	1.6030 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc