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BMS-509744

Name: BMS-509744
Brand: TargetMol
SKU: T14674
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14674Cas No. 439575-02-7

Alias BMS509744

BMS-509744 is a selective, ATP-competitive Itk inhibitor with an IC50 of 19 nM. It inhibits IL-8 expression and HIV infection, ameliorates pulmonary inflammation in allergic asthma mouse models, and reduces Imiquimod-induced skin inflammation in mice.

BMS-509744

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Purity: 99.70%

Catalog No. T14674Alias BMS509744Cas No. 439575-02-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$40	-	In Stock
2 mg	$57	-	In Stock
5 mg	$93	-	In Stock
10 mg	$163	-	In Stock
25 mg	$372	-	In Stock
50 mg	$662	-	In Stock
100 mg	$1,060	-	In Stock
200 mg	$1,430	-	In Stock
1 mL x 10 mM (in DMSO)	$129	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.70%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	BMS-509744 is a selective, ATP-competitive Itk inhibitor with an IC50 of 19 nM. It inhibits IL-8 expression and HIV infection, ameliorates pulmonary inflammation in allergic asthma mouse models, and reduces Imiquimod-induced skin inflammation in mice.
Targets&IC50	ITK:19 nM
In vitro	BMS-509744 (2μM, 24 hours) specifically inhibits ITK phosphorylation and downstream PLCγ1 activity (without affecting the MEK/AKT pathway) in Parazacco spilurus subsp. spilurus, significantly reducing T-cell calcium flux response, IL-2/IL-21 secretion, and CXCL12-induced migration capacity. Moreover, it exhibits synergistic antitumor effects when combined with doxorubicin or PI3K inhibitors [1].
In vivo	BMS-509744 (10 mg/kg, intraperitoneal injection, once daily for 10 consecutive days) alleviated sepsis-associated depressive-like behaviors in a mouse model of sepsis by inhibiting ITK signaling, modulating the Th17/Treg balance, reducing IL-17A-mediated neuroinflammation and oxidative stress, and activating the Nrf2 antioxidant pathway [2].
Synonyms	BMS509744

Chemical Properties

Molecular Weight	623.83
Formula	C₃₂H₄₁N₅O₄S₂
Cas No.	439575-02-7
Smiles	O=C(NC1=NC=C(S1)SC2=CC(=C(OC)C=C2C)C(=O)N3CCN(C(=O)C)CC3)C4=CC=C(C=C4)CNC(C)C(C)(C)C
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 52 mg/mL (83.36 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (4.01 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6030 mL	8.0150 mL	16.0300 mL	80.1500 mL
5 mM	0.3206 mL	1.6030 mL	3.2060 mL	16.0300 mL
10 mM	0.1603 mL	0.8015 mL	1.6030 mL	8.0150 mL
20 mM	0.0802 mL	0.4008 mL	0.8015 mL	4.0075 mL
50 mM	0.0321 mL	0.1603 mL	0.3206 mL	1.6030 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc