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D-AP5

Name: D-AP5
Brand: TargetMol
SKU: T10930
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10930Cas No. 79055-68-8

Alias D-APV, D-2-Amino-5-phosphonovaleric acid

D-AP5 (D-APV) is an NMDA receptor antagonist.

D-AP5

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Purity: 98.77%

Catalog No. T10930Alias D-APV, D-2-Amino-5-phosphonovaleric acidCas No. 79055-68-8

D-AP5 (D-APV) is an NMDA receptor antagonist.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	In Stock	In Stock
2 mg	$40	In Stock	In Stock
5 mg	$64	In Stock	In Stock
10 mg	$113	In Stock	In Stock
25 mg	$239	In Stock	In Stock
50 mg	$477	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$62	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.77%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	D-AP5 (D-APV) is an NMDA receptor antagonist.
Targets&IC50	NMDA:1.4 μM(kd)
In vivo	D-AP5 is an NMDA receptor antagonist. Chronic intraventricular injection of D-AP5 can cause dose-dependent parallel damage to spatial learning and long-term enhancement (LTP) in vivo. When preventing spatial learning, the concentration of D-AP5 in the brain cannot cause any measurable sensorimotor disturbances. Compared with the test, D-AP5 infusion will cause a gradual decrease in swimming speed. D-AP5 causes sensorimotor disturbances in space tasks, but gradually deteriorates due to the inability of animals to learn. Rats treated with D-AP5 showed spatially dependent delay-dependent defects in the delayed matching placement protocol of the water maze.
Synonyms	D-APV, D-2-Amino-5-phosphonovaleric acid

Chemical Properties

Molecular Weight	197.13
Formula	C₅H₁₂NO₅P
Cas No.	79055-68-8
Smiles	C(C[C@H](C(O)=O)N)CP(=O)(O)O
Relative Density.	1.529 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: < 1 mg/mL (insoluble)

H2O: 42.92 mg/mL (217.72 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	5.0728 mL	25.3640 mL	50.7279 mL	253.6397 mL
5 mM	1.0146 mL	5.0728 mL	10.1456 mL	50.7279 mL
10 mM	0.5073 mL	2.5364 mL	5.0728 mL	25.3640 mL
20 mM	0.2536 mL	1.2682 mL	2.5364 mL	12.6820 mL
50 mM	0.1015 mL	0.5073 mL	1.0146 mL	5.0728 mL
100 mM	0.0507 mL	0.2536 mL	0.5073 mL	2.5364 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc