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Amezinium methylsulfate

Name: Amezinium methylsulfate
Brand: TargetMol
SKU: T5327
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5327Cas No. 30578-37-1

Alias Lu-1631, Amezinium metilsulfate, Amezinium (methylsulfate)

Amezinium methylsulfate (Lu-1631) has multiple mechanisms, including stimulation of alpha and beta-1 receptors and inhibition of noradrenaline and tyramine uptake.

Amezinium methylsulfate

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Purity: 99.99%

Catalog No. T5327Alias Lu-1631, Amezinium metilsulfate, Amezinium (methylsulfate)Cas No. 30578-37-1

Amezinium methylsulfate (Lu-1631) has multiple mechanisms, including stimulation of alpha and beta-1 receptors and inhibition of noradrenaline and tyramine uptake.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	$48	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.99%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Amezinium methylsulfate (Lu-1631) has multiple mechanisms, including stimulation of alpha and beta-1 receptors and inhibition of noradrenaline and tyramine uptake.
In vivo	In 5 patients with multiple system atrophy, administration of 15 mg/day of amezinium metilsulfate, an adrenergic agent, during 6 months for the treatment of postural hypotension exacerbated post-micturition residuals as compared to that before treatment (178 ml versus 113 ml for a change of 37 %) [1]. The reduction ratio of FTBF was significantly increased by amezimium [placebo, 75.9%; amezinium, 85.1%; midodrine, 78.1%]. The infusion rate of noradrenaline producing a half-maximum venoconstriction was significantly decreased by amezinium (placebo, 40.6 ng/min; amezinium, 21.0 ng/min) [2].
Synonyms	Lu-1631, Amezinium metilsulfate, Amezinium (methylsulfate)

Chemical Properties

Molecular Weight	313.33
Formula	C₁₂H₁₅N₃O₅S
Cas No.	30578-37-1
Smiles	COS([O-])(=O)=O.COc1cc(N)cn[n+]1-c1ccccc1
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (159.58 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1915 mL	15.9576 mL	31.9152 mL	159.5762 mL
5 mM	0.6383 mL	3.1915 mL	6.3830 mL	31.9152 mL
10 mM	0.3192 mL	1.5958 mL	3.1915 mL	15.9576 mL
20 mM	0.1596 mL	0.7979 mL	1.5958 mL	7.9788 mL
50 mM	0.0638 mL	0.3192 mL	0.6383 mL	3.1915 mL
100 mM	0.0319 mL	0.1596 mL	0.3192 mL	1.5958 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc