Powder: -20°C for 3 years | In solvent: -80°C for 2 years
LEO 39652 is a dual-soft PDE4 inhibitor with IC50s of 1.2 nM, 1.2 nM, 3.0 nM and 3.8 nM for PDE4A, PDE4B, PDE4C and PDE4D, respectively. LEO 39652 also inhibits TNF-α with an IC50 value of 6.0 nM. LEO 39652 is used for topical research of Atopic dermatitis (AD) [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | 5 days | $ 148.00 |
Description | LEO 39652 is a dual-soft PDE4 inhibitor with IC50s of 1.2 nM, 1.2 nM, 3.0 nM and 3.8 nM for PDE4A, PDE4B, PDE4C and PDE4D, respectively. LEO 39652 also inhibits TNF-α with an IC50 value of 6.0 nM. LEO 39652 is used for topical research of Atopic dermatitis (AD) [1]. |
Targets&IC50 | PDE4B:1.2 nM (IC50), TNF-α:6.0 nM (IC50), PDE4C2:3.0 nM (IC50), PDE4D:3.8 nM (IC50), PDE4A:1.2 nM (IC50) |
In vitro | LEO 39652 shows unbound in vitro potency when measured as LPS induced TNF-α release in human peripheral blood mononuclear cells (PBMC), incubated in serum free medium. LEO 39652 shows a relatively high binding to human serum albumin[2]. |
In vivo | LEO 39652 is inactivated both in blood and liver (dual-soft) while stabled in the skin[1].Pharmacokinetic AnalysisLEO 39652 exhibits total clearance (rats 930, minipigs 200 and monkey 300 mL/min/kg) and ratio to total AUC (rats 4, minipigs 6 and monkey 6 %) following intravenous administration (rats 0.075, minipigs 0.5 and monkeys 2.0 mg/kg)[1]. |
Molecular Weight | 421.453 |
Formula | C23H23N3O5 |
CAS No. | 1445656-91-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
DMSO: 25 mg/mL (59.32 mM), Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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LEO 39652 1445656-91-6 inhibitor inhibit