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IRG1-IN-1

Name: IRG1-IN-1
Brand: TargetMol
SKU: T78525
Price: 54 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T78525Cas No. 2407652-42-8

IRG1-IN-1, an itaconic acid derivative, inhibits Immune Response Gene 1 (IRG1) activity and is suitable for cancer, inflammation, and autoimmune disease research.

IRG1-IN-1

😃Good

Purity: 99.69%

Catalog No. T78525Cas No. 2407652-42-8

IRG1-IN-1, an itaconic acid derivative, inhibits Immune Response Gene 1 (IRG1) activity and is suitable for cancer, inflammation, and autoimmune disease research.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$54	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.69%

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COA

Product Introduction

Bioactivity

Description	IRG1-IN-1, an itaconic acid derivative, inhibits Immune Response Gene 1 (IRG1) activity and is suitable for cancer, inflammation, and autoimmune disease research.
In vitro	IRG1-IN-1 (0.5 mM; 1 mM) partially inhibits the proliferation of C-IRG1-9 rat glioma cells [1]. IRG1-IN-1 (0.5 mM; 2 mM) reduces the production of itaconic acid and the secretion of TNFα from human monocyte-derived macrophages (hMDMs) stimulated with LPS [1].IRG1-IN-1 (10μM) shows a decrease in trimethylation of histone 3 at lysine 4 (H3K4me3) in CR-activated hCD8+ T cells [1]. IRG1-IN-1 (10 nM) increases the proliferation of TCR-activated hCD8+ T cells [1].
In vivo	IRG1-IN-1 administered intraperitoneally at a dose of 0.2 mg/kg for 27 days demonstrates a significant anti-tumor effect in C57BL/6 mice [1].

Chemical Properties

Molecular Weight	314.31
Formula	C₁₈H₁₅FO₄
Cas No.	2407652-42-8
Smiles	O=C(O)C(=CC1=CC=C(F)C=C1)C(C(=O)O)CC=2C=CC=CC2
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (254.53 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (10.5 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1816 mL	15.9079 mL	31.8157 mL	159.0786 mL
5 mM	0.6363 mL	3.1816 mL	6.3631 mL	31.8157 mL
10 mM	0.3182 mL	1.5908 mL	3.1816 mL	15.9079 mL
20 mM	0.1591 mL	0.7954 mL	1.5908 mL	7.9539 mL
50 mM	0.0636 mL	0.3182 mL	0.6363 mL	3.1816 mL
100 mM	0.0318 mL	0.1591 mL	0.3182 mL	1.5908 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc