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LY487379
Catalog No. T62756 Copy Product Info
Purity: 99.94%
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LY487379 is a selective mGluR2 positive allosteric modulator (PAM). It potently enhances glutamate-stimulated signaling, with EC50 values of 1.7 μM for mGlu2 and >10 μM for mGlu3 receptors, demonstrating high subtype selectivity. In behavioral models, LY487379 has been shown to promote cognitive flexibility and facilitate behavioral inhibition. It serves as a valuable tool for researching the therapeutic potential of mGluR2 modulation in schizophrenia and related cognitive impairments.
LY487379
Copy Product Info🥰Excellent
Catalog No. T62756
LY487379 is a selective mGluR2 positive allosteric modulator (PAM). It potently enhances glutamate-stimulated signaling, with EC50 values of 1.7 μM for mGlu2 and >10 μM for mGlu3 receptors, demonstrating high subtype selectivity. In behavioral models, LY487379 has been shown to promote cognitive flexibility and facilitate behavioral inhibition. It serves as a valuable tool for researching the therapeutic potential of mGluR2 modulation in schizophrenia and related cognitive impairments.
Cas No. 353231-17-1
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 2 mg | $40 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.94%
Appearance:Solid
Color:Pink
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | LY487379 is a selective mGluR2 positive allosteric modulator (PAM). It potently enhances glutamate-stimulated signaling, with EC50 values of 1.7 μM for mGlu2 and >10 μM for mGlu3 receptors, demonstrating high subtype selectivity. In behavioral models, LY487379 has been shown to promote cognitive flexibility and facilitate behavioral inhibition. It serves as a valuable tool for researching the therapeutic potential of mGluR2 modulation in schizophrenia and related cognitive impairments. |
| Targets&IC50 | mGluR2:1.7 μM(EC50) |
| In vitro | LY487379 is a selective mGluR2 PAM that potentiates glutamate signaling by reducing agonist dissociation, with no direct agonism. It enhances [³⁵S]GTPγS binding in mGlu2-expressing cells (EC₅₀ = 1.7 μM) and exhibits >6-fold selectivity over mGlu3, serving as a standard tool for dissecting Group II mGluR subtype functions [2]. |
| In vivo | LY487379 (30 mg/kg, i.p.) improves cognitive flexibility in rats, reducing trials in the extra-dimensional shift of the ASST. Microdialysis reveals a bell-shaped increase in mPFC norepinephrine and serotonin, a neurochemical mechanism that may underlie enhanced executive function [1]. |
| Molecular Weight | 452.45 |
| Formula | C21H19F3N2O4S |
| Cas No. | 353231-17-1 |
| Smiles | O=S(=O)(N(C1=CC=C(OC=2C=CC=CC2OC)C=C1)CC=3C=NC=CC3)CC(F)(F)F |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (176.82 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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