Shopping Cart

Your shopping cart is currently empty

7-Hydroxyflavone

Name: 7-Hydroxyflavone
Brand: TargetMol
SKU: T7472
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T7472Cas No. 6665-86-7

7-Hydroxyflavone is a potent inhibitor of CYP1A1 with a Ki value of 0.015 μM and exhibits 6-fold greater selectivity for CYP1A1 over CYP1A2.with anti-inflammatory activity

7-Hydroxyflavone

Copy Product Info

😃Good

Purity: 99.79%

Catalog No. T7472Cas No. 6665-86-7

7-Hydroxyflavone is a potent inhibitor of CYP1A1 with a Ki value of 0.015 μM and exhibits 6-fold greater selectivity for CYP1A1 over CYP1A2.with anti-inflammatory activity

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$30	In Stock	In Stock
50 mg	$37	In Stock	In Stock
100 mg	$50	In Stock	In Stock
500 mg	$113	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.79%

Appearance:Solid

Color:White to Gray

Resource Download

COA HNMR HPLC

Product Introduction

7-Hydroxyflavone AI Summary

7-Hydroxyflavone demonstrates a variety of bioactivities across multiple biological assays. It shows inhibitory activity against ALR2 (aldose reductase) with an IC50 value of 14650.0 nM in bovine lenses and against COX-2 catalyzed PGE-2 production in LPS induced RAW 264.7 cells with a 70.8% inhibition rate at 10 µM concentration. It binds to benzodiazepine receptors with a Ki value of 4200.0 nM and interacts with the androgen receptor with an IC50 value greater than 42657.95 nM. Additionally, it shows significant inhibitory activity against hamster liver mitochondrial monoamine oxidase (MAO) with an IC50 of 120.0 nM. 7-Hydroxyflavone also displays low affinity for adenosine A1 and A2A receptors, with pKi values of -0.48 and -0.43 µM, respectively. It effectively lowers systolic blood pressure in anesthetized spontaneously hypertensive rats and provides significant protection from gastric damage in rats. Moreover, it inhibits bovine thymus p56Lck-catalyzed phosphorylation and beef heart mitochondrial enzymes, including a 95.1% inhibition of ATPase activity at 0.42 mM concentration. The compound has shown antiplasmodial activity with an IC50 of 65500.0 nM against Plasmodium falciparum NF54 and also inhibits FabZ enzyme with an IC50 of 20000.0 nM. It demonstrates antioxidant activity by inhibiting toxin-induced lipid peroxidation and shows inhibitory effects on carbonic anhydrase isozymes. 7-Hydroxyflavone induces adipogenesis in mouse 3T3L1 cells and exhibits vasorelaxant properties in Wistar rat thoracic aortic rings. It also shows antagonist activity at the alpha1-adrenoceptor in rat anococcygeal muscle and antiviral activity against Marburg virus and SARS-CoV-2. 7-Hydroxyflavone inhibits human 17beta-HSD1 and 17beta-HSD2 enzymes, demonstrating potential effects in hormone regulation. Furthermore, it exhibits cytotoxicity against human cell lines and moderate inhibition against multiple CYP enzymes, suggesting broad pharmacological properties..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

7-Hydroxyflavone is a potent inhibitor of CYP1A1 with a Ki value of 0.015 μM and exhibits 6-fold greater selectivity for CYP1A1 over CYP1A2.with anti-inflammatory activity

Chemical Properties

Molecular Weight	238.24
Formula	C₁₅H₁₀O₃
Cas No.	6665-86-7
Smiles	Oc1ccc2c(c1)oc(cc2=O)-c1ccccc1
Relative Density.	1.340 g/cm3 at 20℃

Storage & Solubility Information

Storage

keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 47 mg/mL (197.28 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.39 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.1974 mL	20.9872 mL	41.9745 mL	209.8724 mL
5 mM	0.8395 mL	4.1974 mL	8.3949 mL	41.9745 mL
10 mM	0.4197 mL	2.0987 mL	4.1974 mL	20.9872 mL
20 mM	0.2099 mL	1.0494 mL	2.0987 mL	10.4936 mL
50 mM	0.0839 mL	0.4197 mL	0.8395 mL	4.1974 mL
100 mM	0.0420 mL	0.2099 mL	0.4197 mL	2.0987 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc