Shopping Cart

Remove All

Your shopping cart is currently empty

Proceed to checkout Continue shopping

eIF4A3-IN-2

Name: eIF4A3-IN-2
Brand: TargetMol
SKU: T11171
Rating: 4.5 (1 reviews)

😃Good

Catalog No. T11171Cas No. 2095677-20-4

eIF4A3-IN-2 is a highly selective and noncompetitive inhibitor of eukaryotic initiation factor 4A-3, exhibiting an IC50 of 110 nM.

eIF4A3-IN-2

😃Good

Catalog No. T11171Cas No. 2095677-20-4

eIF4A3-IN-2 is a highly selective and noncompetitive inhibitor of eukaryotic initiation factor 4A-3, exhibiting an IC50 of 110 nM.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$523	6-8 weeks	6-8 weeks
25 mg	$1,680	6-8 weeks	6-8 weeks
50 mg	$2,190	6-8 weeks	6-8 weeks
100 mg	$3,270	6-8 weeks	6-8 weeks

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Resource Download

Product Introduction

Bioactivity

Description	eIF4A3-IN-2 is a highly selective and noncompetitive inhibitor of eukaryotic initiation factor 4A-3, exhibiting an IC50 of 110 nM.
Targets&IC50	eIF4A3:110 nM
In vitro	eIF4A3-IN-2 binds to the allosteric region in eIF4A3 and inhibits in vitro ATPase, helicase, and cellular nonsense-mediated RNA decay activities.

Chemical Properties

Molecular Weight	602.71
Formula	C₂₅H₁₉Br₂ClN₄O₂
Cas No.	2095677-20-4
Smiles	Clc1ccc(cc1)[C@H]1CN(CCN1C(=O)c1ccc(Br)cc1)C(=O)c1cnn2cc(Br)ccc12
Relative Density.	1.68 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (165.92 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (3.32 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6592 mL	8.2959 mL	16.5917 mL	82.9586 mL
5 mM	0.3318 mL	1.6592 mL	3.3183 mL	16.5917 mL
10 mM	0.1659 mL	0.8296 mL	1.6592 mL	8.2959 mL
20 mM	0.0830 mL	0.4148 mL	0.8296 mL	4.1479 mL
50 mM	0.0332 mL	0.1659 mL	0.3318 mL	1.6592 mL
100 mM	0.0166 mL	0.0830 mL	0.1659 mL	0.8296 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc