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ML380

Name: ML380
Brand: TargetMol
SKU: T28069
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T28069Cas No. 1627138-52-6

Alias ML-380, ML 380

ML380 is a highly potent and the first CNS penetrant M5 positive allosteric modulator (PAM).

ML380

🥰Excellent

Purity: 99.69%

Catalog No. T28069Alias ML-380, ML 380Cas No. 1627138-52-6

ML380 is a highly potent and the first CNS penetrant M5 positive allosteric modulator (PAM).

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$42	In Stock	In Stock
5 mg	$68	In Stock	In Stock
10 mg	$122	In Stock	In Stock
25 mg	$198	In Stock	In Stock
50 mg	$372	In Stock	In Stock
100 mg	$556	In Stock	In Stock
500 mg	$1,220	-	In Stock
1 mL x 10 mM (in DMSO)	$75	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:99.69%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	ML380 is a highly potent and the first CNS penetrant M5 positive allosteric modulator (PAM).
Targets&IC50	M5 mAChR (human):190 nM, M5 mAChR (rat):610 nM
Synonyms	ML-380, ML 380

Chemical Properties

Molecular Weight	494.53
Formula	C₂₃H₂₅F₃N₄O₃S
Cas No.	1627138-52-6
Smiles	CCN(Cc1ccccc1C(F)(F)F)C(=O)C1CCN(CC1)S(=O)(=O)c1ccc2[nH]ncc2c1
Relative Density.	1.388 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (181.99 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.67 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0221 mL	10.1106 mL	20.2212 mL	101.1061 mL
5 mM	0.4044 mL	2.0221 mL	4.0442 mL	20.2212 mL
10 mM	0.2022 mL	1.0111 mL	2.0221 mL	10.1106 mL
20 mM	0.1011 mL	0.5055 mL	1.0111 mL	5.0553 mL
50 mM	0.0404 mL	0.2022 mL	0.4044 mL	2.0221 mL
100 mM	0.0202 mL	0.1011 mL	0.2022 mL	1.0111 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc