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ML380

Name: ML380
Brand: TargetMol
SKU: T28069
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T28069Cas No. 1627138-52-6

Alias ML-380, ML 380

ML380 is a highly potent and the first CNS penetrant M5 positive allosteric modulator (PAM).

ML380

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Purity: 99.69%

Catalog No. T28069Alias ML-380, ML 380Cas No. 1627138-52-6

ML380 is a highly potent and the first CNS penetrant M5 positive allosteric modulator (PAM).

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$42	In Stock	In Stock
5 mg	$68	In Stock	In Stock
10 mg	$122	In Stock	In Stock
25 mg	$198	In Stock	In Stock
50 mg	$372	In Stock	In Stock
100 mg	$556	In Stock	In Stock
500 mg	$1,220	-	In Stock
1 mL x 10 mM (in DMSO)	$75	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.69%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

ML380 AI Summary

ML380 exhibits positive allosteric modulator activity at the human muscarinic acetylcholine receptor subtype M5, significantly enhancing the acetylcholine-induced response with a fold change of 9.3 and an EC50 of 190.0 nM. It shows high selectivity for subtype M5 over subtypes M1 and M3. The compound also demonstrates significant displacement of radioligand from the human muscarinic acetylcholine receptor subtype M5 and exerts an inhibitory effect on the human CB1 and sigma-1 receptors. Additionally, it has moderate apparent permeability in human Caco2 cells, low plasma clearance, a short elimination half-life, and a moderate volume of distribution at steady state in Sprague-Dawley rats..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	ML380 is a highly potent and the first CNS penetrant M5 positive allosteric modulator (PAM).
Targets&IC50	M5 mAChR (rat):610 nM , M5 mAChR (human):190 nM
Synonyms	ML-380, ML 380

Chemical Properties

Molecular Weight	494.53
Formula	C₂₃H₂₅F₃N₄O₃S
Cas No.	1627138-52-6
Smiles	CCN(Cc1ccccc1C(F)(F)F)C(=O)C1CCN(CC1)S(=O)(=O)c1ccc2[nH]ncc2c1
Relative Density.	1.388 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (181.99 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.67 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0221 mL	10.1106 mL	20.2212 mL	101.1061 mL
5 mM	0.4044 mL	2.0221 mL	4.0442 mL	20.2212 mL
10 mM	0.2022 mL	1.0111 mL	2.0221 mL	10.1106 mL
20 mM	0.1011 mL	0.5055 mL	1.0111 mL	5.0553 mL
50 mM	0.0404 mL	0.2022 mL	0.4044 mL	2.0221 mL
100 mM	0.0202 mL	0.1011 mL	0.2022 mL	1.0111 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc