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Anti-GM-CSF/CSF2 Antibody (2R691) (Synonyms: GM-CSF, GMCSF, CSF2, colony stimulating factor 2 (granulocyte-ma...)
Catalog No. TMAY-03529 Copy Product Info
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Anti-GM-CSF/CSF2 Antibody (2R691) is a Rabbit antibody targeting GM-CSF/CSF2. Anti-GM-CSF/CSF2 Antibody (2R691) can be used in ELISA,ELISA(Cap).
Anti-GM-CSF/CSF2 Antibody (2R691)
Copy Product Info🥰Excellent
Catalog No. TMAY-03529
Synonyms GM-CSF, GMCSF, CSF2, colony stimulating factor 2 (granulocyte-macrophage)
Anti-GM-CSF/CSF2 Antibody (2R691) is a Rabbit antibody targeting GM-CSF/CSF2. Anti-GM-CSF/CSF2 Antibody (2R691) can be used in ELISA,ELISA(Cap).
Anti-GM-CSF/CSF2 Antibody
(2R691)
(2R691)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 20 μL | $92 | 7-10 days | 7-10 days | |
| 100 μL | $270 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | Anti-GM-CSF/CSF2 Antibody (2R691) is a Rabbit antibody targeting GM-CSF/CSF2. Anti-GM-CSF/CSF2 Antibody (2R691) can be used in ELISA,ELISA(Cap). |
| Synonyms | GM-CSF, GMCSF, CSF2, colony stimulating factor 2 (granulocyte-macrophage) |
| Ig Type | Rabbit IgG |
| Clone | 2R691 |
| Reactivity | Mouse |
| Specificity | Mouse GM-CSF/CSF2 |
| Application | |
| Recommended Dose | ELISA: 1:5000-1:10000; ELISA(Cap): 1:250-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse GM-CSF/CSF2 (rM GM-CSF/CSF2; TMPY-03662; P01587; Ala18-Lys141). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Granulocyte-macrophage colony-stimulating factor (GM-CSF) is one of an array of cytokines with pivotal roles in embryo implantation and subsequent development. Several cell lineages in the reproductive tract and gestational tissues synthesise GM-CSF under direction by ovarian steroid hormones and signalling agents originating in male seminal fluid and the conceptus. The pre-implantation embryo, invading placental trophoblast cells and the abundant populations of leukocytes controlling maternal immune tolerance are all subject to GM-CSF regulation. GM-CSF stimulates the differentiation of hematopoietic progenitors to monocytes and neutrophils, and reduces the risk for febrile neutropenia in cancer patients. GM-CSF also has been shown to induce the differentiation of myeloid dendritic cells (DCs) that promote the development of T-helper type 1 (cellular) immune responses in cognate T cells. The active form of the protein is found extracellularly as a homodimer, and the encoding gene is localized to a related gene cluster at chromosome region 5q31 which is known to be associated with 5q-syndrome and acute myelogenous leukemia. As a part of the immune/inflammatory cascade, GM-CSF promotes Th1 biased immune response, angiogenesis, allergic inflammation, and the development of autoimmunity, and thus worthy of consideration for therapeutic target. GM-CSF has been utilized in the clinical management of multiple disease processes. Most recently, GM-CSF has been incorporated into the treatment of malignancies as a sole therapy, as well as a vaccine adjuvant. While the benefits of GM-CSF in this arena have been promising, recent reports have suggested the potential for GM-CSF to induce immune suppression and, thus, negatively impact outcomes in the management of cancer patients. GM-CSF deficiency in pregnancy adversely impacts fetal and placental development, as well as progeny viability and growth after birth, highlighting this cytokine as a central maternal determinant of pregnancy outcome with clinical relevance in human fertility.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Mouse GM-CSF/CSF2 Protein (TMPY-03662) |
| Antigen Species | Mouse |
| Biology Area | Cancer Drug Targets |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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