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JNJ-9350

Name: JNJ-9350
Brand: TargetMol
SKU: T73407
Rating: 4.5 (1 reviews)

(Synonyms: JNJ9350, JNJ 9350) Copy Product Info

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Synonyms: JNJ9350, JNJ 9350

Catalog No. T73407 Copy Product Info

Purity: 98.56%

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JNJ-9350 is a chemical probe that effectively inhibits spermine oxidase (SMOX) with an IC₅₀ of 0.01 μM; it also inhibits polyamine oxidase (PAO) with an IC₅₀ of 0.79 μM, and can be applied to tumor research.

Cas No. 326923-09-5

Pack Size	Price	USA Stock	Global Stock
25 mg	Inquiry	-	In Stock
50 mg	Inquiry	-	In Stock
100 mg	Inquiry	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:98.56%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	JNJ-9350 is a chemical probe that effectively inhibits spermine oxidase (SMOX) with an IC₅₀ of 0.01 μM; it also inhibits polyamine oxidase (PAO) with an IC₅₀ of 0.79 μM, and can be applied to tumor research.
Targets & IC50	PAO:790 nM, SMOX:10 nM
In vitro	Methods: In vitro enzyme activity inhibition assays and binding kinetic experiments were performed to determine the inhibitory activity of JNJ-9350 against SMOX, PAO and LSD1, as well as its binding affinity to SMOX. Results: : 1.JNJ-9350 (0–100 μM) exhibited inhibitory effects on SMOX, PAO and LSD1, with corresponding IC₅₀ values of 10 nM, 790 nM and >60 μM, respectively. 2.JNJ-9350 (1.1–70 μM) could bind to SMOX with an inhibition constant Ki of 9.9 nM [1].
Synonyms	JNJ9350, JNJ 9350

Chemical Properties

Molecular Weight	422.48
Formula	C₂₅H₂₂N₆O
Cas No.	326923-09-5
Smiles	O=C(NCCCN1C=NC=C1)C2=NN3C(N=C(C=C3C=4C=CC=CC4)C=5C=CC=CC5)=C2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 4 mg/mL (9.47 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3670 mL	11.8349 mL	23.6698 mL	118.3488 mL
5 mM	0.4734 mL	2.3670 mL	4.7340 mL	23.6698 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Related Tags: JNJ-9350 chemical structure | JNJ-9350 in vitro | JNJ-9350 formula | JNJ-9350 molecular weight