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ML401

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Catalog No. T8234Cas No. 1597489-14-9

ML401 is a selectively EBI2(GPR183) receptor antagonist(IC50 of 1.03 nM) .

ML401

ML401

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Purity: 99.13%
Catalog No. T8234Cas No. 1597489-14-9
ML401 is a selectively EBI2(GPR183) receptor antagonist(IC50 of 1.03 nM) .
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$50In StockIn Stock
5 mg$118In StockIn Stock
10 mg$193In StockIn Stock
25 mg$308In StockIn Stock
50 mg$413In StockIn Stock
100 mg$535In StockIn Stock
1 mL x 10 mM (in DMSO)$130In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.13%
Appearance:Solid
Color:White
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Product Introduction

Bioactivity
Description
ML401 is a selectively EBI2(GPR183) receptor antagonist(IC50 of 1.03 nM) .
Targets&IC50
EBI2/GPR183:1.03 nM
Chemical Properties
Molecular Weight419.74
FormulaC20H20BrClN2O
Cas No.1597489-14-9
SmilesClc1ccc(CN2CCN(CC2)C(=O)\C=C\c2ccc(Br)cc2)cc1
Relative Density.1.422 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 10 mg/mL (23.82 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.38 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3824 mL11.9121 mL23.8243 mL119.1214 mL
5 mM0.4765 mL2.3824 mL4.7649 mL23.8243 mL
10 mM0.2382 mL1.1912 mL2.3824 mL11.9121 mL
20 mM0.1191 mL0.5956 mL1.1912 mL5.9561 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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