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LCB 03-0110

Catalog No. T9659   CAS 1228102-01-9
Synonyms: 3-(2-(3-(Morpholinomethyl)phenyl)thieno[3,2-b]pyridin-7-ylamino)phenol

LCB 03-0110 (3-(2-(3-(Morpholinomethyl)phenyl)thieno[3,2-b]pyridin-7-ylamino)phenol) is a potent inhibitor of discoidin domain receptor family tyrosine kinases and strongly inhibits several tyrosine kinases, including the c-Src family, spleen tyrosine kinase, Bruton's tyrosine kinase, and vascular endothelial growth factor receptor 2, which are important for immune cell signaling and inflammatory reactions.

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LCB 03-0110 Chemical Structure
LCB 03-0110, CAS 1228102-01-9
Pack Size Availability Price/USD Quantity
1 mg In stock $ 117.00
5 mg In stock $ 262.00
10 mg In stock $ 387.00
25 mg In stock $ 592.00
50 mg In stock $ 828.00
100 mg In stock $ 1,110.00
1 mL * 10 mM (in DMSO) In stock $ 295.00
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Purity: 98.83%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description LCB 03-0110 (3-(2-(3-(Morpholinomethyl)phenyl)thieno[3,2-b]pyridin-7-ylamino)phenol) is a potent inhibitor of discoidin domain receptor family tyrosine kinases and strongly inhibits several tyrosine kinases, including the c-Src family, spleen tyrosine kinase, Bruton's tyrosine kinase, and vascular endothelial growth factor receptor 2, which are important for immune cell signaling and inflammatory reactions.
In vitro In J774A.1 macrophage cells activated by lipopolysaccharide LCB 03-0110 inhibited cell migration and nitric oxide, inducible nitric-oxide synthase, cyclooxygenase 2, and tumor necrosis factor-α synthesis[1].
In vivo LCB 03-0110 applied topically to full excisional wounds on rabbit ears suppressed the accumulation of myofibroblast and macrophage cells in the healing wound and reduced hypertrophic scar formation after wound closing, without delaying the wound closing process[1].
Synonyms 3-(2-(3-(Morpholinomethyl)phenyl)thieno[3,2-b]pyridin-7-ylamino)phenol
Molecular Weight 417.52
Formula C24H23N3O2S
CAS No. 1228102-01-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (107.78 mM)

TargetMolReferences and Literature

1. Sun X, et al. LCB 03-0110, a novel pan-discoidin domain receptor/c-Src family tyrosine kinase inhibitor, suppresses scar formation by inhibiting fibroblast and macrophage activation. J Pharmacol Exp Ther. 2012 Mar;340(3):510-9. 2. Jung SH, et al. Topical administration of the pan-Src kinase inhibitors, dasatinib and LCB 03-0110, prevents allergic contact dermatitis in mice. Br J Dermatol. 2013 Jan;168(1):112-9.

Related compound libraries

This product is contained In the following compound libraries:
Inhibitor Library Membrane Protein-targeted Compound Library Tyrosine Kinase Inhibitor Library Bioactive Compound Library Bioactive Compounds Library Max

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Keywords

LCB 03-0110 1228102-01-9 Tyrosine Kinase/Adaptors Discoidin Domain Receptor (DDR) LCB 030110 3-(2-(3-(Morpholinomethyl)phenyl)thieno[3,2-b]pyridin-7-ylamino)phenol LCB 03 0110 inhibitor inhibit

 

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