IFN-α, a cytokine expressed in human islets from individuals affected by type 1 diabetes, plays a key role in the pathogenesis of diabetes by upregulating inflammation, endoplasmic reticulum (ER) stress and MHC class I overexpression, three hallmarks of islet histology in early type 1 diabetes.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
100 μg | 5 days | $ 487.00 | |
500 μg | 5 days | $ 1,950.00 | |
1 mg | 5 days | $ 3,250.00 |
Description | IFN-α, a cytokine expressed in human islets from individuals affected by type 1 diabetes, plays a key role in the pathogenesis of diabetes by upregulating inflammation, endoplasmic reticulum (ER) stress and MHC class I overexpression, three hallmarks of islet histology in early type 1 diabetes. |
Species | Mouse |
Expression System | HEK293 |
Tag | C-hFc |
Accession Number | P01572 |
Synonyms | IFN-α-1/13, IFN alpha1, Interferon α-1/13, Interferon alpha-1/13, IFNalpha 1, Interferon α-D, IFNA1, IFNα1, IFN-alpha-1, IFN α1, LeIF D, IFN α 1, IFN-α-1, Interferon α1, IFN-alpha-1/13, Interferon alpha 1, Interferon alpha-D |
Construction | Recombinant Mouse IFN alpha 1 Protein is expressed from HEK293 with hFc tag at the C-Terminus. It contains Cys24-Lys189.[Accession |P01572] |
Protein Purity | > 95% as determined by Tris-Bis PAGE |
Molecular Weight | The protein has a predicted MW of 45.88 kDa. Due to glycosylation, the protein migrates to 50-60 kDa based on Tris-Bis PAGE result. |
Endotoxin | Less than 1EU per μg by the LAL method. |
Formulation | Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability & Storage |
-20 to -80°C for 12 months as supplied from date of receipt. -20 to -80°C for 3-6 months in unopened state after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Shipping |
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. |
Research Background | IFN-α, a cytokine expressed in human islets from individuals affected by type 1 diabetes, plays a key role in the pathogenesis of diabetes by upregulating inflammation, endoplasmic reticulum (ER) stress and MHC class I overexpression, three hallmarks of islet histology in early type 1 diabetes. |
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IFN-alpha 1/IFNA1 Protein, Mouse, Recombinant (hFc) IFNA 1 IFN-α-1/13 IFN-a-1 IFN alpha1 Interferon α-1/13 Interferon alpha-1/13 IFNalpha 1 Interferon α-D Interferon a-D IFNA1 Interferon a 1 IFNα1 IFN-alpha-1 IFN α1 LeIF D IFN-a-1/13 Interferon a-1/13 IFN α 1 Interferon α 1 IFN-α-1 IFNα 1 Interferon α1 IFNA-1 IFN-alpha-1/13 Interferon alpha 1 Interferon alpha-D recombinant recombinant-proteins proteins protein