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5-Hydroxyoxindole

Catalog No. T37710   CAS 3416-18-0

5-Hydroxyoxindole has been identified as a urinary metabolite of indole, which is produced from tryptophane via the tryptophanase activity of gut bacteria [1]. 5-Hydroxyoxindole has lipid peroxidation inhibition activity and free radical DPPH scavenging

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5-Hydroxyoxindole Chemical Structure
5-Hydroxyoxindole, CAS 3416-18-0
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Biological Description
Chemical Properties
Storage & Solubility Information
Description 5-Hydroxyoxindole has been identified as a urinary metabolite of indole, which is produced from tryptophane via the tryptophanase activity of gut bacteria [1]. 5-Hydroxyoxindole has lipid peroxidation inhibition activity and free radical DPPH scavenging
In vitro 5-Hydroxyoxindole was less potent MAO-A inhibitor (IC50 56.8 microM) than isatin (31.8 microM) and especially 5-hydroxyisatin (6.5 microM), but it was the only highly selective MAO-A inhibitor among the all compounds studied (IC50 MAO-A:IC50 MAO-B = 0.044) [1].
In vivo In blood plasma, 5-hydroxyoxindole levels were quite stable [2]. The maximal 5-hydroxyoxindole concentration in plasma was: 5.4 nM (5-hydroxyoxindole molecular weight: 149) [2].
Molecular Weight 149.15
Formula C8H7NO2
CAS No. 3416-18-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Michèle Crumeyrolle-Arias, et al. Inhibition of brain mitochondrial monoamine oxidases by the endogenous compound 5-hydroxyoxindole. Biochem Pharmacol. 2004 Mar 1;67(5):977-9. 2. Daisuke Yasuda, et al. Preparation and antioxidant/pro-oxidant activities of 3-monosubstituted 5-hydroxyoxindole derivatives. J Clin Biochem Nutr. 2016 Nov;59(3):165-173.

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Keywords

5-Hydroxyoxindole 3416-18-0 Immunology/Inflammation Metabolism NF-Κb Reactive Oxygen Species antioxidant Inhibitor oxidative ,stress DPPH radical inhibit scavenging peroxidation 5 Hydroxyoxindole lipid 5Hydroxyoxindole inhibitor

 

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