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PNU-177864

Name: PNU-177864
Brand: TargetMol
SKU: T23167
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23167Cas No. 250266-51-4

PNU-177864 is a selective dopamine D3 receptor antagonist.

PNU-177864

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Purity: 99.92%

Catalog No. T23167Cas No. 250266-51-4

PNU-177864 is a selective dopamine D3 receptor antagonist.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$35	-	In Stock
5 mg	$76	-	In Stock
10 mg	$94	-	In Stock
25 mg	$213	-	In Stock
50 mg	$298	-	In Stock
100 mg	$412	-	In Stock
200 mg	$573	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.92%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

PNU-177864 AI Summary

PNU-177864 has demonstrated antiviral activity by inhibiting SARS-CoV-2 induced cytotoxicity in both Caco-2 and VERO-6 cells. Specifically, it showed an inhibition rate of 13.24% at a concentration of 10 µM in Caco-2 cells, and an inhibition percentage of 0.34% at the same concentration in VERO-6 cells after 48 hours. Additionally, PNU-177864 inhibits the SARS-CoV-2 3CL-Pro protease, with an inhibition percentage of 1.416% at a concentration of 20 µM, suggesting potential antiviral properties against SARS-CoV-2. Moreover, the compound exhibits inhibitory activity against human HDAC6, achieving an inhibition percentage of -4.01% with a commercial peptide substrate and 6.93% with a custom peptide substrate in enzymatic assays, indicating potential as an HDAC6 inhibitor..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

PNU-177864 is a selective dopamine D3 receptor antagonist.

Chemical Properties

Molecular Weight	402.43
Formula	C₁₈H₂₁F₃N₂O₃S
Cas No.	250266-51-4
Smiles	N(S(=O)(=O)C1=CC=C(OC(F)(F)F)C=C1)C2=CC=C(CCNCCC)C=C2
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (136.67 mM), Sonication is recommended.

H2O: < 8.78 mg/mL, Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (12.42 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4849 mL	12.4245 mL	24.8490 mL	124.2452 mL
5 mM	0.4970 mL	2.4849 mL	4.9698 mL	24.8490 mL
10 mM	0.2485 mL	1.2425 mL	2.4849 mL	12.4245 mL
20 mM	0.1242 mL	0.6212 mL	1.2425 mL	6.2123 mL
50 mM	0.0497 mL	0.2485 mL	0.4970 mL	2.4849 mL
100 mM	0.0248 mL	0.1242 mL	0.2485 mL	1.2425 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc