S1R agonist 1 hydrochloride

Name: S1R agonist 1 hydrochloride
Brand: TargetMol
SKU: T78086
Rating: 4.5 (1 reviews)

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Catalog No. T78086Cas No. 242487-82-7

S1R Agonist 1 (Compound 6b) hydrochloride is a selective S1R agonist, displaying K i values of 0.93 nM for S1R and 72 nM for S2R, and has demonstrated neuroprotective effects against ROS and NMDA-induced neurotoxicity [1].

S1R agonist 1 hydrochloride

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Catalog No. T78086Cas No. 242487-82-7

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$48	5 days	5 days

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Product Introduction

Bioactivity

Description	S1R Agonist 1 (Compound 6b) hydrochloride is a selective S1R agonist, displaying K i values of 0.93 nM for S1R and 72 nM for S2R, and has demonstrated neuroprotective effects against ROS and NMDA-induced neurotoxicity [1].
In vitro	S1R agonist 1 (Compound 6b; 0.1-5 μM) hydrochloride significantly enhances neurite outgrowth induced by nerve growth factor (NGF) in a dose-dependent manner in PC12 cells and, at 1 μM for 24 hours, inhibits Rotenone-induced damage in SHSY5Y cells [1]. Additionally, it demonstrates neuroprotective effects against NMDA stimulation in SHSY5Y cells at 0.1-5 μM over 24 hours and shows no cytotoxicity in A549, LoVo, and Panc-1 cells at 0-10 μM over 24-72 hours [1].
In vivo	Compound 6b, a selective S1R agonist at concentrations ranging from 0.1 to 50 μM, was administered over 120 hours, resulting in the death of 4 out of 8 zebrafish embryos at a 10 μM concentration [1].

Chemical Properties

Molecular Weight	331.88
Formula	C₂₀H₂₆ClNO
Cas No.	242487-82-7
Smiles	Cl.O(C=1C=CC=CC1)CCN2CCC(CC=3C=CC=CC3)CC2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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