Powder: -20°C for 3 years | In solvent: -80°C for 1 year
S1R Agonist 1 (Compound 6b) hydrochloride is a selective S1R agonist, displaying K i values of 0.93 nM for S1R and 72 nM for S2R, and has demonstrated neuroprotective effects against ROS and NMDA-induced neurotoxicity [1].
Pack Size | Availability | Price/USD | Quantity |
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2 mg | 5 days | $ 48.00 |
Description | S1R Agonist 1 (Compound 6b) hydrochloride is a selective S1R agonist, displaying K i values of 0.93 nM for S1R and 72 nM for S2R, and has demonstrated neuroprotective effects against ROS and NMDA-induced neurotoxicity [1]. |
In vitro | S1R agonist 1 (Compound 6b; 0.1-5 μM) hydrochloride significantly enhances neurite outgrowth induced by nerve growth factor (NGF) in PC12 cells in a dose-dependent manner [1]. Additionally, at a concentration of 1 μM, S1R agonist 1 (24 h) hydrochloride notably inhibits cell damage in SHSY5Y cells caused by Rotenone [1]. The compound also exhibits neuroprotective effects against NMDA stimulation in SHSY5Y cells at 0.1-5 μM over 24 hours [1]. Furthermore, S1R agonist 1 (0-10 μM; 24-72 h) hydrochloride shows no cytotoxicity in A549, LoVo, and Panc-1 cells [1]. |
In vivo | Compound 6b, a selective S1R agonist at concentrations ranging from 0.1 to 50 μM, was administered over 120 hours, resulting in the death of 4 out of 8 zebrafish embryos at a 10 μM concentration [1]. |
Molecular Weight | 331.88 |
Formula | C20H26ClNO |
CAS No. | 242487-82-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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S1R agonist 1 hydrochloride 242487-82-7 GPCR/G Protein Sigma receptor inhibitor inhibit